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Food and Drug Administration (FDA) for use in women who are unable to become pregnant. It affects the hormone balance within the body and promotes ovulation. Clomid is only approved by the FDA for use in women, but it’s sometimes prescribed off-label as an infertility treatment in men. Is Clomid an effective treatment for male infertility? Clomid blocks the hormone estrogen from interacting with your pituitary gland. When estrogen interacts with the pituitary gland, less luteinizing hormone (LH) and follicle-stimulating hormone (FSH) are produced. This leads to a decrease in testosterone and therefore decreased production of sperm. Because Clomid blocks estrogen’s interaction with the pituitary gland, there is an increase in LH, FSH, and testosterone in the body. The dose given can range from 12.5 to 400 milligrams (mg) per day. 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