Generic Name: promethazine (oral) (pro METH a zeen)Brand Names: Phenergan, Phenadoz, Promethegan Phenergan is also found in combination with other medications such as phenylephrine (Prometh Hydrochloride), codeine (Prometh VC), or dextromethorphan (Promethazine DM) Medically reviewed by Kaci Durbin, MD. Phenergan (promethazine) belongs to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. It blocks the effects of the naturally occurring chemical histamine in your body. Phenergan is used to treat allergy symptoms such as itching, runny nose, sneezing, itchy or watery eyes, hives, and itchy skin rashes. Phenergan also prevents motion sickness, and treats nausea and vomiting or pain after surgery. Phenergan is not for use in treating symptoms of asthma, pneumonia, or other lower respiratory tract infections. Stop using Phenergan and call your doctor at once if you have twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs. These could be early signs of dangerous side effects. Phenergan should not be given to a child younger than 2 years old. PHENERGAN 25mg Injection tablet/syrup is used for the treatment of allergic symptoms, such as itching, runny nose, sneezing and rash. It is also recommended for the prevention of nausea, vomiting and motion sickness after surgery. PHENERGAN 25mg Injection injection is used to improve allergic reactions and treat motion sickness. It is also used as a sedative in certain surgeries. PHENERGAN 25mg Injection may also be prescribed for other conditions as determined by the doctor. PHENERGAN 25mg Injection belongs to the class of drugs called anti-histamines. This drug acts by blocking the histamine receptors in the gastrointestinal tract, uterus and bronchial muscle. 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The treatment of choice for resulting hypotension is administration of intravenous fluids, accompanied by repositioning if indicated. In the event that vasopressors are considered for the management of severe hypotension which does not respond to intravenous fluids and repositioning, the administration of norepinephrine or phenylephrine should be considered. EPINEPHRINE SHOULD NOT BE USED, since its use in a patient with partial adrenergic blockade may further lower the blood pressure. Extrapyramidal reactions may be treated with anticholinergic antiparkinson agents, diphenhydramine, or barbiturates. Limited experience with dialysis indicates that it is not helpful. 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