Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take leflunomide with all of your drugs and health problems. Chloroquine and prime Chloroquine diphosphate salt solubility Conventional DMARDs that have been paired with methotrexate include sulfasalazine, hydroxychloroquine, cyclosporine, leflunomide and azathioprine. Although studies of these combinations have shown differing levels of benefit, the combinations of methotrexate plus leflunomide and methotrexate plus sulfasalazine are among the most effective. Leflunomide is the generic form of the brand-name medicine Arava, which is used to treat rheumatoid arthritis a condition in which the body attacks its own joints. This prescription medication. Nov 01, 2018 CHICAGO – Combination therapy with leflunomide and hydroxychloroquine met all goals for efficacy, safety, and tolerability among patients with primary Sjögren’s syndrome in a randomized, placebo-controlled pilot study, lending support to evidence suggesting the two drugs have additive benefits. WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Leflunomide and hydroxychloroquine Leflunomide Indications, Side Effects, Warnings -, Leflunomide Arava - Side Effects, Dosage, Interactions. Does plaquenil increase risk of infectionDoes plaquenil treat ckdPlaquenil lungsPlaquenil side effects on heartPlaquenil drug guide This study evaluates the efficacy of the combination of methotrexate and hydroxychloroquine against leflunomide, a new DMARD as initial therapy in severe active rheumatoid arthritis. Hydroxychloroquine is known to increase the potency of methotrexate as well as increase its safety profile and reduce the dose. Evaluation of efficacy of combination of methotrexate and.. Leflunomide-hydroxychloroquine combo shows promise in primary.. Pilot Trial in Sjögren’s Shows Potential of Leflunomide-Hydroxychloroquine. Background/Purpose Primary Sjogren’s syndrome pSS is a systemic, progressive autoimmune disease characterized by secretory gland dysfunction which lacks effective therapy. Clinical trials in patients with pSS using leflunomide LEF or hydroxychloroquine HCQ previously effectively inhibited B cell hyperactivity, but induced only modest insignificant effects on clinical parameters. LEF. Rheumatoid Arthritis Medication Beware of Sunburn if You Take These Drugs. A side effect of some RA medicine is sun sensitivity. Be extra careful to avoid skin burns, blistering, and the. We compare the side effects and drug effectiveness of Hydroxychloroquine sulfate and Leflunomide. The study is created by eHealthMe based on reports of 132,232 people who take Hydroxychloroquine sulfate and Leflunomide, and is updated regularly. On eHealthMe, you can evaluate side effects and drug interactions from 16 million FDA reports.