I saw a GP about it (not my usual one) and they strongly suspect it is being caused by MTX but I have just spoken to the Rheumy nurse who thinks Hydroxy is the more likely suspect or it may be an autoimmune response so now I have to withhold all rheumy meds. It seems to improve when I am on steroids but only at higher doses. Thanks, Tamara I am on all sorts of meds including MTX and Hydroxy. What side effects does plaquenil have on your teeth Hydroxychloroquine lupus erythematosus Ibuprofen and plaquenil Hydroxychloroquine interaction Skin rash or itching; or; hair loss. This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. What is the most important information I should know about hydroxychloroquine Plaquenil, Plaquenil Sulfate, Quineprox? Find information about common, infrequent and rare side effects of Plaquenil Oral. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. I can't face the GP again, as I am sure I am one of the "heart-sink" patients! I have recently developed an itchy rash which only affects my cheeks and eyebrows and haven't a clue what's causing it, so I hope you get some helpful replies that might help me too! What does a plaquenil rash look like Ask the Expert Plaquenil and Sjögren’s, Common and Rare Side Effects for Plaquenil Oral Rheumatoid arthritis hydroxychloroquine 200 mg Plaquenil “. gas, fatigue, diarrhea, some hallucinations, which have subsided as of now, hyper pigmentation, purpura and petechiai med size and small size red pepper dots on skin, have had a rash on abdomen for 3. ” Hydroxychloroquine Sulfate Rash Reports - DrugInformer. Lupus Medicines Hydroxychloroquine - Brigham and Women's.. Allergic reaction to plaquenil DailyStrength. I broke out with a rash after being on it for a week. I was also on a mild muscle relaxer for about 3 weeks prior to plaquenil. I got off both then started back on plaquenil. No rash so I assumed it was the other med even though I was on it longer and before the plaquenil. Did not resume the other meds. I've been on Plaquenil for 6 weeks. I developed a red, raised, welt rash that looked like zebra stripes after being in the sun for 10 minutes. It went away within 30 minutes but then my joints all flared up the next few days. Check with your doctor! Rheumatoid arthritis is a systemic inflammatory conditions that causes joint pain, swelling, inflammation, and nodes or hard lumps under the skin.