As a result, the body produces antibodies that inflict cell damage, most commonly targeting joints, skin, kidneys and the nervous system. I recently started taking it in September and it seems like after about 5-10 minutes of taking it, I feel super tired and sleepy. Maybe try taking it with food and see if that helps. if your symptoms persist, you may need a change of dose. Join the group and find support for coping with lupus. I have read about the side effects and I do get the stomache discomfort but is the tiredness normal? but you may want to make sure your not taking too much. hugs I have been taking Plaquenil for quite a few years now, I don't think it's the Plaquenil making you tired...good ol' Lupus. I take 400mg a day and now 2 x Cyclosporin...to mention all the other stuff (I swear when I walk you can hear the rattle! Hi Phoebe, I have been on plaquenil for many years and have not experienced a sudden onset of fatigue after taking it. As Melissa stated plaquenil typically comes in 200mg tablets and 800 mg really seems like an aweful huge dose. Did your doctor tell you to take 2 tabs twice daily or you base on the label on your med bottle. How long chloroquine tablets is good after expiration date Plaquenil help trans mylitis Hydroxychloroquine 400 mg side effects A recent large study of people with cardiovascular disease found that hydroxychloroquine Plaquenil does not increase the risk of infection and methotrexate increases the risk of infection only slightly. The concern with immune suppression is that the virus could replicate more freely and cause more severe or extensive disease, says Dr. Winthrop. SIDE EFFECTS. The following adverse reactions have been identified during post-approval use of PLAQUENIL or other 4-aminoqunoline compounds. Because these reactions are reported voluntarily from a population of uncertain size, it is not always possible to reliably estimate their frequency or establish a causal relationship to drug exposure. We are on the verge of a global pandemic and this particularly unknown vaccine will arrive too late even if successful in the clinic and won't stop the spread of the SARS-CoV2 virus. Even worse. I've also tried to take 1 pill every couple of hours and that still doesn't prevent the fatigue feeling.... I usually take one in the morning and one at night. So far, I don't see any difference, but I guess it takes time. You might want to double check with your rheumy or prescribing doctor to inquire about your current dose and advise of your symptoms. I don't think there is a 100 mg tab, unless it is specially compounded. I have to take two pills in the am and two pills i the pm...sometimes I almost want to just skip the dose in the morning because it makes me feel worse than if I don't take anything. If so, I have never heard of anyone being on 800mg of plaquenil. You can look up the therapeutic doses online and it will tell you the highest dose you can take. Maybe that is why you are so tired after taking them. Taking it with food stops you feeling sick, and yes it takes a long time to kick in... While those of us with lupus never truly find anything to relieve fatigue, plaquenil is suppose to help with fatigue rather than create more from what I understand. The most I have ever taken is 400mg, I am currently on 300mg. I think there is probably some error or misunderstanding or miscommunication going on. Does plaquenil make a virus worse Hydroxychloroquine Side Effects, Dosage, Uses, and More, Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses Plaquenil rheumatoid arthritis side effectsPlaquenil nail discolorationDoes plaquenil treat rhupusPlaquenil and methotrexate for sjogren's syndromeCan plaquenil give you lymphoma WebMD explains the causes, symptoms, and treatment of Sjogren's syndrome, a condition in which your eyes, mouth, and other parts of your body get dried out. Sjogren's Syndrome Symptoms, Causes, Diagnosis, Treatment. Coronavirus There is still a glimpse of hope. Does Plaquenil actually work for you? autoimmunity. Doctor's note Does ibuprofen make coronavirus worse. When the virus enters the human body, it induces mild to severe respiratory problems, a high fever, cough and, potentially, multi-organ. Sep 19, 2010 I do remember it took about 8 weeks before I noticed any difference at all. At three months I saw a big difference, and after six months, I am see a lot of difference. Before taking Plaquenil, I could barely walk. Everyone is different, so if a med is making you feel worse, I think you should let your doctor know and consider trying something else. Feb 09, 2012 I have never been told exactly what Plaquenil does for SLE. I just know my Rheumatologist put me on it. I stopped going to him because he was so negative and I lost an entire year with my family and friends because I was scared to death that being outside in the heat or cold would make me worse.