Hydroxychloroquine in lupus nephritis

Discussion in 'Online Canadian Pharmacy' started by Symon, 22-Feb-2020.

  1. dpol New Member

    Hydroxychloroquine in lupus nephritis


    -Suppressive therapy should continue for 8 weeks after leaving the endemic area. -Each dose should be taken with a meal or a glass of milk.

    Plaquenil 200 mg tablet adalah Ra treatment plaquenil methotrexate Plasmodium falciparum chloroquine resistance first seen

    Despite all these benefits, hydroxychloroquine is too often still regarded as a second-line treatment, as we see from major randomised trials in which only about 50% of patients are treated with hydroxychloroquine, and even more strikingly from the absence of any mention of hydroxychloroquine in important studies. In a study of membranous lupus nephritis, 38 patients were treated with corticosteroids and azathioprine; after 12 months of treatment, 67% of patients had a complete remission and 22% had a partial remission, with only 11% resistant to treatment. Long-term follow-up of 12 years showed 19 episodes of renal flares. Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus.

    -Concomitant therapy with an 8-aminoquinoline drug is necessary for the radical cure of vivax and malariae malaria. Use: Malaria prophylaxis Acute attack: 800 mg (620 mg base) orally followed in 6 to 8 hours by 400 mg (310 mg base), then 400 mg (310 mg base) once a day for 2 consecutive days; alternatively, a single dose of 800 mg (620 mg base) has also been effective Alternate dosing based on body weight: A total dose representing 25 mg/kg is administered in 3 days, as follows: First dose: 10 mg base/kg (not to exceed 620 mg base) orally Second dose: 5 mg base/kg (not to exceed 310 mg base) orally 6 hours after first dose Third dose: 5 mg base/kg orally 18 hours after second dose Fourth dose: 5 mg base/kg orally 24 hours after third dose Comments: -Each dose should be taken with a meal or a glass of milk.

    Hydroxychloroquine in lupus nephritis

    Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus Center, Lupus Nephritis Treatment & Management Approach.

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  7. In 1941, discoid lupus patients were treated successfully with Atabrine, a compound developed in Germany in the 1920s. In the mid-1940s, both hydroxychloroquine HCQ and chloroquine CQ had been synthesized. In 1955 HCQ was shown to be effective for both systemic lupus and rheumatoid arthritis.

    • Drug spotlight on hydroxychloroquine Lupus Foundation of America.
    • Treating Lupus with Anti-Malarial Drugs Johns Hopkins..
    • Protective Effect of Hydroxychloroquine on Renal Damage in Patients..

    Usual Adult Dose for Rheumatoid Arthritis. -Initial dose 400 to 600 mg 310 to 465 mg base orally once a day to optimum response usually 4 to 12 weeks -Maintenance dose 200 to 400 mg 155 to 310 mg base orally once a day Dose adjustment The dose may need to be reduced temporarily if adverse side effects occur; Plaquenil has active ingredients of hydroxychloroquine sulfate. It is often used in systemic lupus erythematosus. It is often used in systemic lupus erythematosus. Check the latest outcomes from 53,829 Plaquenil users, or browse all drugs. Evaluation the efficacy of chloroquine and hydroxychloroquine in the treatment of proliferative lupus nephritis class III and IV in children and adolescents and evaluate the side effects of both drugs.

     
  8. Volkov08 Well-Known Member

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Hydroxychloroquine Side Effects, Dosage, Uses, and More Elevated liver enzymes in Plaquenil how severe and when it. Protecting your eyesight when taking Plaquenil Lupus.
     
  9. voxunity Well-Known Member

    Progression of Hydroxychloroquine Retinopathy The potential for chloroquine phosphate and hydroxychloroquine sulfate retinopathy to progress after cessation of the drug has long been recognized, 1-4 primarily in patients with severe ring scotoma or a visible bull’s-eye lesion in the fundus. Such progression could continue for many years after the drug was stopped.

    Chloroquine - Prescription Drug Information.