Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take chloroquine with all of your drugs and health problems. Is plaquenil safe in pregnancy Can hydroxychloroquine cause diarrhea Plaquenil and metformin Chloroquine has a long half-life, which can vary between 74 hours and 50 days, depending on the cumulative dose. The drug can remain in the skin for 6–7 months after the cessation of therapy. Chloroquine dosing. Chloroquine phosphate is dispensed as a 250 mg tablet, which is equivalent to 155 mg chloroquine base. Mechanism of action of Chloroquine It interferes with the metabolism and hemoglobin utilization by the parasites by binding to and inhibiting the DNA and RNA polymerase. It also concentrates within the parasite vesicles and interferes with the acid-base balance of the parasite inhibiting the growth of the parasite. Its mechanism of action is unknown; however, malarial parasites invade human red blood cells, and chloroquine may prevent malarial parasites from breaking down metabolizing hemoglobin in human red blood cells. For all uses of chloroquine: WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Do not start, stop, or change the dose of any drug without checking with your doctor. Chloroquine phosphate mechanism of action Aralen, Chloroquine phosphate chloroquine dosing., Chloroquine Nivaquine, Resochin Healing Is Divine. Plaquenil for recurrent pregnancy lossChloroquine hpvPlaquenil cause muscle pain Mechanism of Action. Chloroquine is an antimalarial agent. While the drug can inhibit certain enzymes, its effect is believed to result, at least in part from its interaction with DNA. However, the mechanism of plasmodicidal action of chloroquine is not completely certain. CHLOROQUINE PHOSPHATE TABLETS, USP 250 MG and 500 MG. Aralen chloroquine Malaria Drug Side Effects & Dosage. Hydroxychloroquine and Chloroquine Phosphate - RheumaKnowledgy. Action of chloroquine phosphate in rheumatoid arthritis. II. Chromosome damaging effect. Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. Full text Full text is available as a scanned copy of the original print version. Get a printable copy PDF file of the complete article 601K, or click on a page image below to browse page by page. Links to PubMed are also available for Selected References.