Chloroquine mechanism of action slideshare

Discussion in 'North West Pharmacy Canada' started by k1tt1e, 08-Mar-2020.

  1. fiksius XenForo Moderator

    Chloroquine mechanism of action slideshare


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Mechanism of Action Chloroquine, a 4-aminoquinoline, is an anti-protozoal agent. The precise mechanism by which Chloroquine exhibits activity is not known. Chloroquine, may exert its effect against Plasmodium species by concentrating in the acid vesicles of the parasite and by inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Aminoquinoline, excellent schizonticide, Antimalarial, amebicide, anti inflammatory and local irritant. Mechanism of Action of Chloroquine Malarial parasites digest their own haemoglobin and release highly toxic heme. This heme is used up by parasitic polymerase enzyme and converted to non toxic haemozoin. Since Chloroquine is. Mechanism of action Chloroquine basic concentrates in parasite food vacuole acidic. Prevent heme polymerization into hemozoin causing heme accumulation toxic to parasite. Drug complex with heme disrupt cell membrane function. Other mechanism include intercalating of parasite DNA, DNA synthesis inhibition.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine mechanism of action slideshare

    Chloroquine C18H26ClN3 - PubChem, Chloroquine Pharmacology & Usage Details Medicine India

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  5. Although the precise mechanism remains to be determined, the anticancer effects of chloroquine may partially be because of its inhibitory action on macroautophagy hereafter referred to as autophagy.

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    MECHANISM OF ACTION  Acts on trophozoites.  Has no effect on cysts.  Nitro group of metronidazole is reduced by protozoan leading to cytotoxic reduced product that binds to DNA and proteins resulting into parasite death.  is active against the invasive form in gut and liver.  The metronidazole metabolites are taken up into bacterial DNA, and form unstable molecules. Mefloquine• Quinoline methanol derivative developed to deal with chloroquine resistant malaria• Rapidly acting erythrocytic schizonticide, slower than chloroquine & quinine• Effective against chloroquine sensitive & resistant plasmodia• Mechanism of action similar to chloroquine 32. Inhibition of DNA replication is proposed as a general mechanism of the antimicrobial action of chloroquine. The drug chloroquine is bactericidal for Bacillus megaterium ; it inhibits DNA and RNA.

     
  6. Pavelgordi XenForo Moderator

    La cerveza, el vino y el licor fuerte contienen alcohol. Para que sirve hydroxychlor - Salud - Will you have Alcohol interaction with Plaquenil - eHealthMe Plaquenil Hydroxychloroquine - Side Effects, Dosage.
     
  7. FahionTV Well-Known Member

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION DailyMed - HYDROXYCHLOROQUINE SULFATE tablet, film coated Pill Identification Wizard
     
  8. myzabor New Member

    Lupus Medications and Treatments Hydroxychloroquine is used to treat malaria, and researchers have found that this drug also helps with lupus flares. These drugs work well with mild to moderate cases of lupus. They can help.

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