In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Is hydroxychloroquine generic Plaquenil and the flu Early annual screening for patients that have risk factors for developing hydroxychloroquine toxicity. SIGNS. Early signs visual field defects on 10-2 HVF usually paracentral, perifoveal and parafoveal thinning of the retina with loss of the inner/outer segment junction on SD-OCT, increased or decreased signal on autofluorescence, central. Visual field testing Automated VF testing can be valuable in detecting early changes in the retina and, in a reliable patient, can be the most sensitive test to detect such changes Figure 2. 3,4 Standard 10-2 white SITA testing with pattern deviation is recommended for screening the central and parafoveal areas. Today it is recommended that every single person on Plaquenil get a visual field 10-2 test, plus one of the three other highly sensitive screening tests the FAF fundus autofluorescence imaging, the SD-OCT spectral domain optical coherence, or the multifocal electroretinogram mfERG,” Thomas says. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Visual field testing for plaquenil toxicity Plaquenil Toxicity Screening - Retina Group of New York, Retina Today - Imaging in Hydroxychloroquine Toxicity April. Mint hydroxychloroquine Misinterpretation of Humphrey visual field HVF findings in patients utilizing hydroxychloroquine HCQ can lead to delay in diagnosis of retinal toxicity. Early retinopathy has been defined as an acquired, persistent paracentral scotoma visualized on automated visual field testing without any observable fundus changes. Humphrey visual field findings in hydroxychloroquine toxicity.. Protecting your eyesight when taking Plaquenil Lupus.. Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS. The molecular weight of hydroxychloroquine sulfate is 433.95, and molecular formula is C 18 H 26 ClN 3 O. H 2 SO 4. Plaquenil hydroxychloroquine sulfate tablets contain 200 mg hydroxychloroquine sulfate, equivalent to 155 mg base, and are for oral administration. Inactive Ingredients Dibasic calcium phosphate USP. The main outcomes were toxicity as determined by characteristic visual field loss or retinal thinning and photoreceptor damage. They also examined risk factors and prevalence. The study findings revealed that when hydroxychloroquine was used at doses 5mg /kg, the risk of retinopathy was 1% in the first 5 yrs. 2% in 10 yrs. 20 % after 20 yrs. Hydroxychloroquine, sold under the brand name Plaquenil Sanofi-Aventis, is an antimalarial drug that has gained widespread use in treating various autoimmune diseases, including systemic lupus erythematosus and rheumatoid arthritis. 1 By some estimates, more than 150,000 patients are on long-term therapy with this medication in America alone. 2 Retinal toxicity associated with HCQ use is.