Although it is uncommon, lupus can also attack a patient’s liver, causing a more pronounced elevation in liver enzymes, such as ASTs and ALTs. When this happened to me, my symptoms included pervasive malaise, nausea, itching, and worsening of my overall health and lupus activity. Plaquenil charting Ocular testing for plaquenil Taking 4mg plaquenil Increased serum level of liver enzymes is a common finding in patients with systemic lupus erythematosus SLE. Hepatotoxic drugs, viral hepatitis and fatty liver are thought to be the main causes of hepatic lesion in these patients. Hi Wimpy12 - I have PsA and my first biologic was Enbrel, along with Plaquenil. My doctor also tried adding in MTX, Arava, and several other DMARDS but my liver enzymes would rise. So used Enbrel alone and it worked great, have since switched to Cimzia and it is working good too. Liver enzyme abnormality was defined as a 10-fold or greater increase in aspartate aminotransferase and alanine aminotransferase. Acute toxic hepatitis was diagnosed, which rapidly returned to normal after cessation of the suspected causative medication, hydroxychloroquine, and subsequent administration of mycophenolate mofetil. They consulted and referred me to a gastroenterologist. My family doctor was persistent in finding an answer, and wouldn’t let my rheumatologist rest until they found one. Plaquenil and liver enzymes Will you have Elevated liver enzymes with Plaquenil., Plaquenil and Enbrel - Arthritis - Inspire Hydroxychloroquine weigh Liver enzymes are present in liver cells and are spilled out into the bloodstream when there is an injury or illness to the liver. According to the Mayo Clinic, the two most common liver enzymes that are released and tested for are alanine transaminase, or ALT, and aspartate transaminase, or AST. Rheumatoid Arthritis & Elevated Liver Enzymes Healthfully. Hydroxychloroquine-induced toxic hepatitis in a patient.. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses. The doctor just phoned and said my liver enzymes are up and to defintately stop the Plaquenil. I am so disappointed, I am not sure where to go from here. My rheumatologist is not back until the 15th, he was hoping the Plaquenil wouldn't cause any problems. That I had high liver enzymes. All I want to do is sleep, I also hurt in my stomach most of the time. My urine is very dark I don t get hungry. I was on Nexuim but stopped. Can plaquenil cause liver damage Chronic liver damage causes Liver damage caused by iud. Liver Enzymes. The liver produces several enzymes involved in metabolism. Among them, the aminotransferases, also called the transaminases, ALT and AST, which function in protein metabolism, have particular diagnostic value, as they become elevated in several diseases, including those of the liver and gallbladder in addition to disorders of other tissues, including the heart and muscle.