Ocular effects of chloroquine therapy

Discussion in 'Hydroxychloroquine Plaquenil' started by seomember, 21-Feb-2020.

  1. colegial Moderator

    Ocular effects of chloroquine therapy

    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    Its therapeutic action against falciparum malaria is similar to that of chloroquine. It is preferred for treatment of rheumatoid arthritis, lupus erythematosus, and sarcoidosis because the ocular toxic effects are minimal. 24 The dose is 200 to 400 mg/d. Hydroxychloroquine Plaquenil and chloroquine cause ocular toxicity to various parts of the eye such as the cornea, ciliary body, and retina. Chloroquine can also induce cataract formation; however, no reports of hydroxychloroquine and cataract have been reported 1. Oct 01, 2018 It is recommended that Chloroquine be discontinued if ocular toxicity is suspected and the patient should be closely observed given that retinal changes and visual disturbances may progress even after cessation of therapy. Central Nervous System Effects

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Ocular effects of chloroquine therapy

    Ocular complications of chloroquine and derivatives therapy., Hydroxychloroquine toxicity - EyeWiki

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  3. Chloroquine accumulates in the retinal pigment cells resulting in damage to those cells. The common clinical finding is a bull’s eye appearance of the pigment cells in the macula responsible for the central clear vision. This results in blurred vision, distorted vision, loss of color vision.

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    Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. More in Eye Health. If you are taking Plaquenil to treat an inflammatory condition or malaria, you should be aware of the side effects that may occur to your eyes and vision. Plaquenil hydroxychloroquine is in a class of drugs called disease-modifying anti-rheumatic drugs, which are used to decrease inflammation, pain and joint damage. Arrhythmogenic drugs There may be an increased risk of inducing ventricular arrhythmias if chloroquine is used concomitantly with other arrhythmogenic drugs, such as amiodarone or moxifloxacin. Ampicillin In a study of healthy volunteers, chloroquine significantly reduced the bioavailability of ampicillin.

  4. tasteart Moderator

    Applies to hydroxychloroquine: oral tablet Along with its needed effects, hydroxychloroquine (the active ingredient contained in Plaquenil) may cause some unwanted effects. Rx Side Effects New Plaquenil Guidelines and More - American. Rx Side Effects New Plaquenil Guidelines and More. Hydroxychloroquine Plaquenil
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    A Guide To Perioperative Management Of The Rheumatoid Patient. In general, one should consider withdrawal of the medication three or four days prior to surgery. Hydroxychloroquine is a less commonly utilized disease modifying anti-rheumatic medication. It is an anti-malarial medication. There is no indication that Plaquenil requires discontinuation in the perioperative period. In Conclusion

    Taking Plaquenil for Rheumatoid Arthritis
  7. Exact Guest

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