Methotrexate is one of the most commonly used drugs to treat RA. However, it can decrease the levels of an important vitamin in your body called folate. 400 mg hydroxychloroquine Hydroxychloroquine order online Hydroxychloroquine toxicity retina Chloroquine hydrochloride formulation Compare Methotrexate vs Plaquenil head-to-head with other drugs for uses, ratings, cost, side effects, interactions and more. Methotrexate rated 6.7/10 vs Plaquenil rated 6.8/10 in overall patient satisfaction. Methotrexate is a potent folic acid antagonist and so many doctors prescribe folic acid to help with the side effects of methotrexate, such as nausea. But she has MTHFR and folic acid is toxic for her, hence he switched her to the methylated version, L-5-Methylfolate. Side effects can develop if the methylfolate dose is too high. Plaquenil hydroxychloroquine is an effective medication for autoimmune conditions and malaria that comes with less side effects than other DMARDs. Otrexup methotrexate is the first-choice treatment for many types of cancer and arthritis, but it has many side effects. Your doctor may suggest you take a folic acid supplement, which is a manufactured form of folate. This leads to a side effect of methotrexate called folate deficiency. Methotrexate and folic acid and plaquenil for lupus Compare Methotrexate vs Plaquenil for Lupus - Comprehensive., Methotrexate MTHFR folic acid Lupus Forums at The Lupus Site How does plaquenil help autoimmune diseasesPlaquenil classificatinChloroquine phosphate for lupus The good news These common side effects can often be short-circuited by taking a folic acid supplement. Folic acid is the synthetic form of folate. One study found that rheumatoid arthritis RA patients on methotrexate who took folic acid supplements lowered the risk of GI problems and mouth sores by 79 percent. Methotrexate Managing Side Effects Arthritis Foundation. Compare Plaquenil vs Methotrexate -. Compare Hydroxychloroquine vs Methotrexate - Comprehensive Analysis by.. An early variation of the drug, aminopterin was initially developed in 1947 by researchers led by Sidney Farber. It was a chemical analog of folic acid. Methotrexate, proposed as a treatment for leukemia in 1950, was a further variation on folic acid. A weekly dose of methotrexate can cause unpleasant side effects, so Dooley recommends taking it when you have a couple of days off. For example, on Fridays, if you work during the week. “If you don’t feel 100 percent afterward, you have the weekend to get through it,” she says. It’s also important to avoid alcohol while taking methotrexate. Hi JJinIN- I am recently diagnosed with lupus. My rheumatologist prescribed plaquenil, neurontin, prednisone, methotrexate, folic acid, and reglan. I take 7.5mg of the methotrexate weekly and I started three weeks ago. I have had no problems at all with nausea, diarrhea, or any other symptoms.