When I do sleep, upon waking it feels like I never slept. Is this a common side effect and will it subside with time? Hydroxychloroquine monitoring guidelines Chloroquine cos-7 Quinacrine and hydroxychloroquine lupus profundus Protecting your eyesight when taking Plaquenil With all of the physical and emotional complications that lupus can cause, it’s easy to overlook symptoms that seem minor at first. But take this advice Don’t ignore changes in vision. Plaquenil and cold medicines. Liseo 06/04/2008. I cannot tell that the Plaquenil bothers anything except my stomach if I dont eat before taking it. I take Tylenol cold and sinus night time formula. Seems OK. I dont always take the full dose and give more time between doses than recommended. When I first started Plaquenil, I was taking it with food during the day. I would have stomach pains, gas and diarrhea shortly after I took the pill. I stated taking them at night, as suggested on here by another member, and I did not have the diarrhea, pain or the gas. It works for me. Hello I have just been reading that plaquenil can cause insomnia and nightmares which I suffer with. Ive helped x Never taken mine at night so can't comment on that. I read the insert that came with the prescription and it didn't mention insomnia. Can i take plaquenil at night Immune & Autoimmune - Lupus don't want to take plaquenil anymore, Plaquenil and cold medicines DailyStrength Dwarflionfish and chloroquine Oct 11, 2010 Caution, plaquenil is to only be taken orally! I take mine with a quarter glass of milk in the morning and at night. How do you take Plaquenil?. New to Plaquenil - question for you. Plaquenil Side Effects Go Away? DailyStrength. Yes, there are some GI issues in the first few weeks and you need to be patient. I had life threatening issues that sent me to the ER - twice - and each time, Plaquenil brought me back from the brink and set me on an even keel. Please be patient and try to tough out the GI issues and give it 2-3 months. I have just been reading that plaquenil can cause insomnia and nightmares which I suffer with. I take my plaquenil with my evening meal. When is the best time to take it? Would it be best in the morning? I also take in the morning thyroxine, omeprazole and co-codamol, would it interfere with any of those if I took it in the morning instead of. How to use Plaquenil. Lupus and/or rheumatoid arthritis patients will most likely take this medication by mouth, usually once or twice daily or as directed. Hydroxychloroquine generally is given to adults in doses of 200 mg or 400 mg per day. In some cases, higher doses can be used.