Plaquenil is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. Plaquenil fullfield erg severe decrese amplitude Effects of long term use of plaquenil The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. However, it is important that you speak to your doctor before taking any NSAIDs if you are on low-dose aspirin therapy, since certain NSAIDs such as ibuprofen Advil, Motrin, Rufen can interfere with the effectiveness of this treatment. Stomach bleeding and ulcers can become life threatening, so if you take aspirin or have aspirin-sensitive asthma or allergic reactions to aspirin, you should not take Celebrex. Other Precautions You may not be able to take an antidepressant such as Cymbalta, Prozac or Paxil while taking Celebrex as this may lead to complications, such as bruising or bleeding easily. Plaquenil is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. This medicine is not effective against all strains of malaria. Can i take aleve with plaquenil Ibuprofen and Plavix Warning Can You Take Them Together?, Treating Lupus with NSAIDs Johns Hopkins Lupus Center How is chloroquine manufactured Plaquenil is a slow-acting drug, meaning that it can take up to 6 months to experience the full benefits of this medication, but it is possible for symptoms to improve in as few as 1 or 2 months. Plaquenil and other antimalarials are the key to controlling lupus long-term, and some lupus patients may be on Plaquenil for the rest of their lives. Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus. Can You Take Other Pain Meds Along With Celebrex.. Can you take Aleve and plaquinil - Answers. Summary Systemic lupus erythematosus is found among people who take Aleve, especially for people who are female, 60+ old, have been taking the drug for 5 - 10 years, also take medication Plaquenil, and have Rheumatoid arthritis. You can take Tylenol acetaminophen AND Advil OR Aleve. Do not take both Aleve and Advil as they are the same class NSAIDs. If you wish for more pain control, you can take tylenol acetaminophen as directed & also take one of the NSAID's in between Tylenol acetaminophen. You can take Advil or another NSAID while taking Plaquenil hydroxychloroquine as long as NSAID isn't contraindicated for you. Home;. Yes you can take Ibuprofen up to 800 mg, take it with food.