Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Benadryl and hydroxychloroquine Plaquenil dosage maculopathy Plaquenil increase liver enzymes One of the potential long-term side-effects of using anti-malarial medications such as hydroxychloroquine Plaquenil, chloroquine, and quinacrine is the development of dark-colored patches on the skin. They often appear brown, black, or black and blue and tend to develop on the legs, especially around the shins. A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Hydroxychloroquine is considered safer than chloroquine during pregnancy and lactation. Hydroxychloroquine is rapidly absorbed from the gastrointestinal tract, and steady-state concentrations are reached after 4–6 weeks; 45% of hydroxychloroquine binds to plasma proteins that are deposited in tissues such as the liver, spleen, kidney, and lung. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Chloroquine hyperpigmentation pictures face Chloroquine Oral Uses, Side Effects, Interactions, Pictures., Chloroquine Indications, Side Effects, Warnings - Humira vs plaquenil Skin pigmentation related to antimalarials is described as yellow brown to slate gray or black pigmentation, which predominates on the anterior side of the shins but can also be seen in the face, forearms, mouth mucosa essentially hard palace and gingivae and nail beds. 16 This is consistent with our findings because all patients had skin pigmentation lesions on the anterior side of their legs. Hydroxychloroquine-Induced Pigmentation in Patients With.. Hydroxychloroquine DermNet NZ. Mechanisms Regulating Skin Pigmentation The Rise and Fall of.. Mucocutaneous hyperpigmentation because of anti-malarial therapy has been reported since World War II 2; however, HCQ-associated hyperpigmentation seems to be less common than with other antimalarials such as chloroquine 3,4. Jul 11, 2017 Most of the symptoms of porphyria cutanea tarda appear on the skin. Common symptoms include blisters on skin that’s exposed to the sun, including the hands, face, and arms. photosensitivity, which means your skin is sensitive to the sun. thin or fragile skin. increased hair growth, usually on the face. Addison's disease can affect the skin and cause hyperpigmentation. Pictured is the hand of a person suffering from Addison's associated hyperpigmentation alongside the hand of a person who does not have the condition, but who comes from a similar ethnic background. An accident or illness can worsen the skin hyperpigmentation of Addison's disease.