Her rheumatologist instructed her to undergo a baseline ocular examination prior to initiating Plaquenil (hydroxychloroquine, Sanofi-Aventis) therapy. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Although the incidence of macular toxicity is infrequent with Plaquenil use (at a dosage of 200mg or 400mg q.d.), its visual impact can be devastating. Chloroquine resistance mechanism Does plaquenil work for scleroderma Does plaquenil interact with alcohol One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. Multi-focal Electroretinography mfERG may be considered medically necessary for detecting chloroquine Aralen and hydroxychloroquine Plaquenil toxicity. mfERG is considered experimental, investigational and/or unproven for all other indications, including but not limited to the diagnosis and evaluation of glaucoma and the prediction of. Purpose. To determine the validity of multifocal electroretinography mfERG as a screening tool for detecting chloroquine Aralen, Sanofi Aventis, Bridgewater, NJ CQ and hydroxychloroquine Plaquenil, Covis Pharmaceuticals, Inc, Zug, Switzerland HCQ retinal toxicity in patients using these medications. Initially, central visual acuity may be unaffected, but the patient may notice related paracentral scotomas that often interfere with reading. The associated classic retinal toxicity is described as a bull’s eye maculopathy (ring of depigmented retinal pigment epithelium that spares the foveal area). Mferg plaquenil Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus, Electroretinography ERG, Multi-focal Electroretinography. Plaquenil and prednisone for rheumatoid arthritis A 57-year-old female presented to the Ophthalmology clinic at UIHC complaining bilateral central photopsias for the past two years. She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine Plaquenil 200mg bid 6.5mg/kg for 10 years, which was stopped one year prior to. Hydroxychloroquine Plaquenil Toxicity and.. Hydroxychloroquine and Chloroquine Retinopathy A Systematic.. Retinal Physician - New Screening Guidelines for.. Roquine Plaquenil; Sanofi, and generic formulations. The effects of toxic medications can be detected and quantified using ERG. Which type of ERG to apply depends on the mechanism and site of retinal toxic-ity. Identifying retinal toxicity due to chloroquine or hydroxychloroquine is a pertinent application of mfERG. SIGNS OF TOXICITY The multifocal electroretinogram multifocal ERG, mfERG provides objective information on localized retinal function to help find early toxic retinopathy. This is Why You Need Multifocal ERG if You Have Plaquenil Patients What does Plaquenil/hydroxychloroquine do to your eyes? The retina is the film in the back of your eyes. CQ and HCQ can both cause maculopathy or retinopathy. Prior to modern diagnostic techniques, your eye doctor was looking for bull’s eye maculopathy with a dilated exam.