Cutaneous hyperpigmentation during therapy with hydroxychloroquine

Discussion in 'Generic & Brand Canadian Pharmacy' started by aleg, 02-Mar-2020.

  1. Cutaneous hyperpigmentation during therapy with hydroxychloroquine


    B, Brown pigmentation on the legs in another patient who had systemic lupus erythematosus associated with diffuse discoid lupus. The skin biopsy was performed on the brown area distant from discoid lesions.

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    What is drug-induced skin pigmentation. Drug-induced skin pigmentation accounts for 10–20% of all cases of acquired hyperpigmentation. Pigmentation may be induced by a wide variety of drugs; the main ones implicated include non-steroidal anti-inflammatory drugs NSAIDs, phenytoin, antimalarials, amiodarone, antipsychotic drugs, cytotoxic drugs, tetracyclines, and heavy metals. Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. We report two cases of hydroxychloroquine‐induced hyperpigmentation presenting in a 50‐year‐old Caucasian female case 1 and a 78‐year‐old female case 2, both receiving 400 mg per day. Case 1 had an arthritis predominant undifferentiated connective tissue disease, which was treated with hydroxychloroquine for 4–5 years.

    B, Presence of iron in the same areas of the dermis (Perls staining, original magnification ×100). Pub Med Google Scholar Crossref Morrison LK, Nordlund JJ, Heffernan MP. Pub Med Google Scholar Costedoat-Chalumeau N, Galicier L, Aumaître O, et al; Group PLUS. Google Scholar Costedoat-Chalumeau N, Amoura Z, Hulot JS, et al. Pub Med Google Scholar Crossref Costedoat-Chalumeau N, Leroux G, Piette J-C, Amoura Z. A, Interstitial and perivascular brown pigmented granules in the dermis (hematoxylin-eosin-safran staining, original magnification ×100).

    Cutaneous hyperpigmentation during therapy with hydroxychloroquine

    Will you have Skin hyperpigmentation with Plaquenil - eHealthMe, Hydroxychloroquine Side Effects Common, Severe, Long Term.

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  4. Aug 14, 2013 Hydroxychloroquine is an antimalarial medication that can cause hyperpigmentation of nails, mucosa, and skin 1–5. Retrospective studies cite the incidence of drug-related hyperpigmentation from hydroxychloroquine to be as high as 33% of individuals. Elder abuse is a cause of significant morbidity and mortality in older individuals 7–9.

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    Amichai B, Gat A, Grunwald MH. Cutaneous hyperpigmentation during therapy with hydroxychloroquine. JCR Journal of Clinical Rheumatology 13 113, No. 2, Apr 2007 - Israel Background Antimalarials including hydroxychloroquine HCQ have been used in the treatment of systemic lupus erythematosus SLE for more than 50 years. Few cases of hyperpigmentation attributed to HCQ have been reported in the literature from different geographical areas. Skin Hyperpigmentation with Hydroxychloroquine. Hydroxychloroquine Plaquenil is a common trade name is an anti-inflammatory oral medication that is commonly used to treat many autoimmune diseases. In the hair clinic, we use it for diseases such as lichen planopilaris, frontal fibrosing alopecia, pseudopelade and discoid lupus.

     
  5. metoflex New Member

    After several months your doctor will check your joints for swelling and see how you feel. If you must stop it, it will take a while for the side effects to go away. Hydroxychloroquine how long to take effect? - NRAS How long does it take for plaquenil hydroxychloroquine to work with. Hydroxychloroquine MedlinePlus Drug Information
     
  6. Zeoshnik Guest

    How long does Hydroxychloroquine stay in your system? Hydroxychloroquine has an extremely long half life of around 32 days. This means that every 32 days, half of the previous amount of hydroxychloroquine in the body disappears. It takes around 5.5 half lives for a drug to be completely eliminated from your body meaning that you may need to wait for around 176 days.

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  7. Evian700 User

    Hydroxychloroquine Plaquenil Tablets - United Pharmacies. Plaquenil Hydroxychloroquine is used for a number of conditions. This drug is sometimes prescribed to prevent malaria although it is not effective against chloroquine-resistant malaria. It can also treat malaria attacks. In addition to malaria, this drug may be prescribed as a treatment for auto-immune diseases such as lupus and rheumatoid arthritis.

    Buy Prescription Hydroxychloroquine Sulfate Plaquenil.