Lasix and pregnancy

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    Lasix and pregnancy


    Edema associated with congestive heart failure (CHF), liver cirrhosis, and renal disease, including nephrotic syndrome 20-80 mg PO once daily; may be increased by 20-40 mg q6-8hr; not to exceed 600 mg/day Alternative: 20-40 mg IV/IM once; may be increased by 20 mg q2hr; individual dose not to exceed 200 mg/dose Refractory CHF may necessitate larger doses Excessive diuresis may cause dehydration and electrolyte loss in elderly; lower initial dosages and more gradual adjustments are recommended (eg, 10 mg/day PO)Increase in blood urea nitrogen (BUN) and loss of sodium may cause confusion in elderly; monitor renal function and electrolytes Anaphylaxis Anemia Anorexia Diarrhea Dizziness Glucose intolerance Glycosuria Headache Hearing impairment Hyperuricemia Hypocalcemia Hypokalemia Hypomagnesemia Hypotension Increased patent ductus arteriosus during neonatal period Muscle cramps Nausea Photosensitivity Rash Restlessness Tinnitus Urinary frequency Urticaria Vertigo Weakness Toxic epidermal necrolysis, Stevens-Johnson Syndrome, erythema multiforme, drug rash with eosinophila and systemic symptoms, acute generalized exanthematous pustulosis, exfoliative dermatitis, bullous pemphigoid purpura, pruritus Agent is potent diuretic that, if given in excessive amounts, may lead to profound diuresis with water and electrolyte depletion Careful medical supervision is required; dosing must be adjusted to patient's needs Use caution in systemic lupus erythematosus, liver disease, renal impairment Concomitant ethacrynic acid therapy (increases risk of ototoxicity) Risks of fluid or electrolyte imbalance (including causing hyperglycemia, hyperuricemia, gout), hypotension, metabolic alkalosis, severe hyponatremia, severe hypokalemia, hepatic coma and precoma, hypovolemia (with or without hypotension) Do not commence therapy in hepatic coma and in electrolyte depletion until improvement is noted IV route twice as potent as PO Food delays absorption but not diuretic response May exacerbate lupus Possibility of skin sensitivity to sunlight Prolonged use in premature neonates may cause nephrocalcinosis Efficacy is diminished and risk of ototoxicity increased in patients with hypoproteinemia (associated with nephrotic syndrome); ototoxicity is associated with rapid injection, severe renal impairment, use of higher than recommended doses, concomitant therapy with aminoglycoside antibiotics, ethacrynic acid, or other ototoxic drugs To prevent oliguria, reversible increases in BUN and creatinine, and azotemia, monitor fluid status and renal function; discontinue therapy if azotemia and oliguria occur during treatment of severe progressive renal disease FDA-approved product labeling for many medications have included a broad contraindication in patients with a prior allregic reaction to sulfonamides; however, recent studies have suggested that crossreactivity between antibiotic sulfonamides and nonantibiotic sulfonamides is unlikely to occur In cirrhosis, electrolyte and acid/base imbalances may lead to hepatic encephalopathy; prior to initiation of therapy, correct electrolyte and acid/base imbalances, when hepatic coma is present High doses ( 80 mg) of furosemide may inhibit binding of thyroid hormones to carrier proteins and result in transient increase in free thyroid hormones, followed by overall decrease in total thyroid hormone levels In patients at high risk for radiocontrast nephropathy furosemide can lead to higher incidence of deterioration in renal function after receiving radiocontrast compared to high-risk patients who received only intravenous hydration prior to receiving radiocontrast Observe patients regularly for possible occurrence of blood dyscrasias, liver or kidney damage, or other idiosyncratic reactions Cases of tinnitus and reversible or irreversible hearing impairment and deafness reported Hearing loss in neonates has been associated with use of furosemide injection; in premature neonates with respiratory distress syndrome, diuretic treatment with furosemide in the first few weeks of life may increase risk of persistent patent ductus arteriosus (PDA), possibly through a prostaglandin-E-mediated process Excessive diuresis may cause dehydration and blood volume reduction with circulatory collapse and possibly vascular thrombosis and embolism, particularly in elderly patients Increases in blood glucose and alterations in glucose tolerance tests (with abnormalities of fasting and 2 hour postprandial sugar) have been observed, and rarely, precipitation of diabetes mellitus reported Patients with severe symptoms of urinary retention (because of bladder emptying disorders, prostatic hyperplasia, urethral narrowing), the administration of furosemide can cause acute urinary retention related to increased production and retention of urine; these patients require careful monitoring, especially during initial stages of treatment Hypokalemia may develop with furosemide, especially with brisk diuresis, inadequate oral electrolyte intake, when cirrhosis is present, or during concomitant use of corticosteroids, ACTH, licorice in large amounts, or prolonged use of laxatives Pregnancy category: C; treatment during pregnancy necessitates monitoring of fetal growth because of risk for higher fetal birth weights Lactation: Drug excreted into breast milk; use with caution; may inhibit lactation Loop diuretic; inhibits reabsorption of sodium and chloride ions at proximal and distal renal tubules and loop of Henle; by interfering with chloride-binding cotransport system, causes increases in water, calcium, magnesium, sodium, and chloride Solution: Fructose10W, invert sugar 10% in multiple electrolyte #2 Additive: Amiodarone (at high concentrations of both drugs), buprenorphine, chlorpromazine, diazepam, dobutamine, eptifibatide, erythromycin lactobionate, gentamicin(? ), isoproterenol, meperidine, metoclopramide, netilmicin, papaveretum, prochlorperazine, promethazine Syringe: Caffeine, doxapram, doxorubicin, eptifibatide, metoclopramide, milrinone, droperidol, vinblastine, vincristine Y-site: Alatrofloxacin, amiodarone (incompatible at furosemide 10 mg/m L; possibly compatible at 1 mg/m L), chlorpromazine, ciprofloxacin, cisatracurium (incompatible at cisatracurium 2 mg/m L; possibly compatible at 0.1 mg/m L), clarithromycin, diltiazem, diphenhydramine, dobutamine, dopamine, doxorubicin (incompatible at furosemide 10 mg/m L and doxorubicin 2 mg/m L; possibly compatible at furosemide 3 mg/m L and doxorubicin 0.2 mg/m L), droperidol, eptifibatide, esmolol, famotidine(? ), fenoldopam, gatifloxacin, gemcitabine, gentamicin(? ), hydralazine, idarubicin, labetalol, levofloxacin, meperidine, metoclopramide, midazolam, milrinone, morphine, netilmicin, nicardipine, ondansetron, quinidine, thiopental, vecuronium, vinblastine, vincristine, vinorelbine Not specified: Tetracycline Additive: Cimetidine, epinephrine, heparin, nitroglycerin, potassium chloride, verapamil Syringe: Heparin Y-site: Epinephrine, fentanyl, heparin, norepinephrine, nitroglycerin, potassium chloride, verapamil(? ), vitamins B and C Injection: Inject directly or into tubing of actively running IV over 1-2 minutes Administer undiluted IV injections at rate of 20-40 mg/min; not to exceed 4 mg/min for short-term intermittent infusion; in children, give 0.5 mg/kg/min, titrated to effect Use infusion solution within 24 hours The above information is provided for general informational and educational purposes only. Individual plans may vary and formulary information changes. Contact the applicable plan provider for the most current information. It may not be safe to take the diuretic furosemide (Lasix) if you're pregnant. Although it hasn't been studied in pregnant women, the Food and Drug Administration lists furosemide as a Category C drug, which means that it's been found to present risks in animals. In animal studies, large doses of furosemide -- higher than the equivalent human doses -- have caused harm to the mother and the developing fetus.

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    PREGNANCY CATEGORY C Furosemide lasix has been shown to cause unexplained maternal deaths and abortions in rabbits at 2, 4 and 8 times the maximal recommended human dose. Avoidance of inter-pregnancy weight gain, increased rest at home in the third trimester, and. hypertensive disorders during pregnancy. Furosemide Lasix Oct 2, 2018. Any woman can develop preeclampsia after her baby is born, whether she experienced high blood pressure during her pregnancy or not.

    Pregnancy Category C is given to medicines that show side effects to the fetus in animal studies but no studies in pregnant women have been done. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. A pregnancy Category C medicine may still be given to a pregnant woman if a healthcare provider believes that the benefits to the woman outweigh any possible risks to the unborn child. However, it is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, as mentioned, furosemide may be given to pregnant women if a healthcare provider believes that the benefits outweigh any possible risks. Generally, the drug should be used in pregnant women only when absolutely necessary. It is generally not recommended for treating high blood pressure during pregnancy. Furosemide is a potent diuretic which increases dramatically urine output in most patients. It is most frequently used in patients who are fluid overloaded such as in congestive heart failure. Potassium , sodium and magnesium can be lost in excess with the use of Furosemide and must be closely monitored. It is much stronger than other diuretics used for A single dose of 0.25mg of Alprazolam will not cause harm, however benzodiazepine medications such as Alprazolam and others, when used regularly can significant increase the risk of cleft palate and other structural development, especially in the first trimester. Consult with both your ob/gyn and your prescribing doctor before using such meds. Read more It is safe as long as you watch what you eat and take your vitamins like at home. The only concern is that most miscarriages occur in the first trimester whether you are at home or overseas and it can be more traumatic if you are away from home but the travel doesn't increase the risk. Read more Any blood in the urine during any trimester of pregnancy is not normal and need to be investigated and treated it can be due to urinary tract infection, kidney stones, kidney disorder or cancer it can also be in women who have medical conditions like lupus, sickle cell disease and diabetes. Read more Hello, If you are pregnant and bleeding, it could be due to implantation and or early signs of miscarriage. Keep in mind, just because you have spotting/bleeding, it doesnt mean that you will end up with a miscarriage but follow up with ob-gyn is important. Read more Your ovaries are minimally hormonally active during pregnancy after the first trimester when the placenta takes over the production of estrogen and Progesterone from the corpus luteum. Read more While Metronidazole is listed as a risk category b, it is not safe in the first trimester, because of possible association with congenital defects it may be acceptable in 2nd and 3rd trimesters if alternatives failed.

    Lasix and pregnancy

    Torsemide vs Lasix Main Differences and Similarities - SingleCare, Preeclampsia -

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  5. AU TGA pregnancy category C US FDA pregnancy category C Comments Use of this drug during pregnancy requires monitoring of electrolytes, hematocrit, and fetal growth. See references. Furosemide Breastfeeding Warnings. Caution is recommended as use is contraindicated according to some authorities. Excreted into human milk Yes

    • Furosemide Use During Pregnancy.
    • Still at Risk - Preeclampsia Foundation.
    • If I am pregnant, is it safe to take furosemide? Diuretic..

    From this study, it could be concluded that prescribing diuretics during pregnancy was associated with. with furosemide treatment. Hypertens Pregnancy. Lasix Furosemide belongs to the class of medications called diuretics. This medication should not be used during pregnancy unless the benefits outweigh the. Lasix Injection 20mg/2ml - Summary of Product Characteristics SmPC by SANOFI. work, in general, show no hazardous effect of furosemide in pregnancy.

     
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