Prednisone works by blocking "key steps in the allergic and inflammatory response, including the production and secretion of the so-called inflammatory mediators such as histamine, prostaglandins, and leukotrienes by white blood cells." As Dr. Murray, a a naturopathic physician, who wrote Natural Alternatives to Over-the-Counter and Prescription Drugs (William Morrow & Co., Inc., 1994), points out, disrupting the normal defense reaction of white cells stops the inflammatory response, but "essentially cripples the immune system." Long-term use of prednisone has many side-effects. At doses higher than 10 mg per day, some of the common side effects of long-term use are depression and other mental or emotional disturbances, high blood pressure, diabetes, peptic ulcers, acne, excessive facial hair in women, insomnia, muscle cramps and muscle weakness, thinning and weakening of the skin, osteoporosis, and increased susceptibility to blood clot formation. Since long-term use also suppresses the adrenal glands' production of natural corticosteroids, discontinuing the drug suddenly can result in collapse and even death. According to Murray, Preparations of proteolytic enzymes—including Serratia peptidase—have been shown to be useful in a wide range of inﬂammatory situations.(1) Serratia peptidase better known as Serrapeptase, "The natural Chelation-Anti-Inflammatory" has had wide clinical use - spanning over twenty-five years throughout Europe and Asia - as a viable alternative to salicylates, ibuprofen and the more potent NSAIDs. Unlike these drugs, Serrapeptase is a naturally occurring, physiological agent with no inhibitory effects on prostaglandins and is devoid of gastrointestinal side effects. Serrapeptase, a main Ingredient in Serracor-NK and Serra RX260, helps immensely as it clears out all of the inflammation and dead tissue. Methylprednisolone is used to treat conditions such as arthritis, blood disorders, severe allergic reactions, certain cancers, eye conditions, skin/kidney/intestinal/lung diseases, and immune system disorders. It decreases your immune system's response to various diseases to reduce symptoms such as swelling, pain, and allergic-type reactions. Methylprednisolone may also be used with other medications in hormone disorders. Take this medication by mouth as directed by your doctor, usually with food or milk. The dosage and length of treatment are based on your medical condition and response to treatment. Different dosing schedules exist for this medication. If you are not taking the same dose each day or if you take this medication every other day, it may help to mark your calendar with a reminder. Consult your doctor or pharmacist if you have any questions. Do not increase your dose or use this drug more often or for longer than prescribed. 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The steroid is associated with a number of harmful side effects, however, and some people would prefer using an herbal alternative to avoid the potential side effects associated with steroid use. Scientists are now beginning to reveal highly effective herbal alternatives to prednisone use. Prednisone is a steroid with the ability to stop inflammation from occurring; this medication can be prescribed for the treatment of extreme allergies, skin disorders and rashes, ulcerative colitis, and breathing difficulties. The steroid is indeed powerful as an anti-inflammatory, but the numerous side effects make it a medication that is not good for long term uses. Prednisone can diminish immunological functioning, and the complete course of the medication must be taken exactly as prescribed to reduce the risk of withdrawal symptoms. Most SJIA kids whose disease is not controlled by biologic drugs take glucorticoid steroids of some kind (prednisone is the most common). Steroids work well in controlling inflammation, but come at a tremendous cost: stunted growth, fragile bones, cataracts, and weakened muscle are some of the side-effects. But we put up with it because the alternative of uncontrolled SJIA is worse. Eric Hoffman, a researcher in another childhood disease (Duchenne Muscular Dystrophy), gave the keynote at our next-gen SJIA treatments conference in October. He is leading an effort at Reveragen to bring a steroid replacement called Vamorolone (generic name VBP15) to market. The goal of the drug is to replicate the good effects of steroids (primarily their anti-inflamatory effect) without the side effects. The way that the drug works is by modifying steroids so that the transrepression effects are removed. Prednisone substitutes NATURAL ALTERNATIVES TO CORTISONE Drug-free Strategies to., Prednisone Uses & Side Effects + 7 Surprising Natural Alternatives. 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