Please review the following URL and make sure that it is spelled correctly. Hi everybody, I was wondering if Plaquenil's primary mode of action was to suppress the immune system? Plaquenil maculopathy visual field Can you just stop taking hydroxychloroquine What do plaquenil pills look like 2 hydroxychloroquine sulfate plaquenil sulfate Yes, Plaquenil suppresses the immune system. Autoimmune disease such as Sjogrens occurs when the body gets "confused" and attacks healthy tissue instead of just attacking the germs. Basically, the immune system is a bit out of control. Plaquenil works by suppressing the immune system. Methotrexate does suppress the immune system, but serious infections with methotrexate are not common. Your rheumatologist will monitor you closely for any side effects associated with methotrexate such as liver test abnormalities, pneumonitis, or infections. Almost all autoimmune diseases require the immune system be suppressed to some degree. I've been on Plaquenil for almost 2 wks now and I'm also taking Prednisone, could one of these be causing my extreme stomach cramps? 2 nights ago, I had a cheeseburger and mac and cheese and I thought I was going to die about 1 in the morning. I ended up throwing up once and then I had diarrhea for a bit and then it passed once my system cleared. 1 month ago and prior to taking it I rarely ever got sick with colds,flu etc. I am asking this question, because I started this med approx. Plaquenil and immune system Having lupus, and being on plaquenil. Does that mean I have a., Methotrexate Does it weaken my immune system? Chloroquine poisoning antidoteDoi need to take prednisone with plaquenil Plaquenil itself probably does not have a direct affect on your immune system - it is a DMARD and is not considered to be an immunosuppressant. However, many with active autoimmune diseases feel that they are not succeptible to many of the common viruses that they are exposed to - somewhat of a silver lining. Anyone on Hydroxychloroquine plaquenil - Autoimmune diseases - Inspire. Plaquenil and stomach issues." Lupus Community - Support.. Plaquenil Use in Autoimmune Diseases. Summary Immunodeficiency disorders is found among people who take Plaquenil, especially for people who are female, 60+ old, have been taking the drug for 6 - 12 months, also take medication Humira, and have Mixed connective tissue disease. These medications may also prevent lupus from spreading to certain organs, such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus long term, and some lupus patients may be on Plaquenil for the rest of their lives. Our immune system is an amazing network of cells that protects us from infectious diseases and watches for damage to our own cells. Sometimes, however, the system goes awry and misreads signals. As a result, our immune system fails to recognize its own body and begins “attacking” its body.