Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Plaquenil fda package insert Plaquenil helps.me.sleep Plasmodium falciparum chloroquine resistance first seen Anti-malarial medications have shown to improve muscle and joint pain, skin rashes, pericarditis, and other lupus symptoms such as fatigue and fever. such as the kidney and central nervous system your brain and spinal cord and may help to reduce flares by as much as 50%. Plaquenil and other anti-malarials are the key to controlling lupus. Hi Ides, I have found your question because, after taking Plaquenil for 2 weeks, I have extreme lower back pain. I checked out 'side effects of Plaquenil' on the Internet before contacting my Rheumy. On stopping the medication for 24 hours I had an improvement. It sounds like your RA has probably gotten a bit out of control, relative, to your current treatment, and Plaquenil is not a particularly potent drug when it comes to managing joint pain. I've been. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Does plaquenil reduce pain Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Plaquenil can cause back and leg pain? What type? Act or chloroquine malaria I went in to my Rheum this week because I was having a lot more pain, burning, and muscle fatigue, particularly in my legs and arms, especially at night while I'm trying to sleep. He told me to stop the Plaquenil because sometimes it can cause nerve damage. He told me to stop it for two weeks and come back in. He said nerve damage is a side effect. Plaquenil and nerve damage - Scleroderma - Inspire. Plaquenil and pain" Rheumatoid Arthritis Community.. Plaquenil Hydroxychloroquine - Side Effects, Dosage.. Hydroxychloroquine is a DMARD. The brand name is Plaquenil. What does Plaquenil do? Plaquenil relieves pain and swelling and prevents damage to joints. How long does Plaquenil take to work? Plaquenil works very slowly. In 1 to 3 months you should start to feel better. You may continue to get better for up to 1 year. Plaquenil reduces inflammation in many Rheumatic disorders, the mode of action is pretty complicated though so I shan't bore you with all the details, but basically it prevents your dendritic cells these are messengers for your immune system, if you will from interacting with your T-Cells a special type of white blood cell which through a convoluted and boring process, causes inflammation. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system.