These medications are initially used in the prophylaxis and treatment of malaria. Plaquenil has replaced chloroquine because it produces less retinal side effects. Plaquenil and liver problems Ester c and plaquenil Chloroquine concentration transfection Hydroxychloroquine cardiac side effects Is there really a scarcity in cases, though? New information shows that hydroxychloroquine retinal toxicity occurs 7.5 percent of the time, which is not that rare. 3. In those patients who are affected, their daily dose and duration of use varied widely. What is plaquenil? Plaquenil is a medication commonly used in patients that have Rheumatoid Arthritis RA, Systemic Lupus Erythematosus SLE, Sjogrens Syndrome, and other inflammatory and autoiummune disorders. What are risk factors for developing retinal toxicity from Plaquenil? Age older than 60; Daily dose of more than 6.5mg/kg This article is from June 2011 and may contain outdated material. Download PDF. Many systemic medications may cause retinal toxicity. One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine Plaquenil, a chloroquine derivative. The toxicity resulting from the intake of Plaquenil is due to its affinity for melanin-containing structures in the body. Aside from its initial intended use, it has been also used for the management of rheumatoid arthritis, systemic lupus erythematosus and several other connective tissue disorders . Retinal toxicity from plaquenil Retinal Physician - Hydroxychloroquine Maculopathy An Update., Dr. Noskow's Case Report Plaquenil Toxicity - Hollywood Eye Institute Hydroxychloroquine pulmonary fibrosis Importance Hydroxychloroquine sulfate is widely used for the long-term treatment of autoimmune conditions but can cause irreversible toxic retinopathy. Prior estimations of risk were low but were based largely on short-term users or severe retinal toxicity bull’s eye maculopathy. Toxic Retinopathy With Hydroxychloroquine Therapy. Hydroxychloroquine-Induced Retinal Toxicity - American.. New Screening Guidelines for Hydroxychloroquine Toxicity. The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy. Lyons emphasizes the importance of annual screening and says that, although annual screening is recommended for everyone taking Plaquenil, it is imperative for people who have been taking the medication for more than 10 years, who have a higher incidence of retinal toxicity. Plaquenil-induced toxicity usually will not occur before five years of. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1.