While the mechanism is poorly understood, pregnant women have a reduced immune response and therefore less effectively clear malaria infections. In addition, malaria parasites sequester and replicate in the placenta. Chloroquine storage conditions Chloroquine major issue Does plaquenil reduce spleen inflammation A baby’s body and most internal organs are formed during the first 12 weeks of pregnancy. It is mainly during this time that some medicines are known to cause birth defects. There is currently no scientific evidence to suggest that women who take chloroquine in pregnancy have a higher chance of having a baby with a birth defect. Hydroxychloroquine Pregnancy Warnings Animal studies have revealed evidence of fetal harm. Use of chloroquine and other 4-aminoquinolines in high doses and for prolonged durations has been associated with neurological disturbances and interference with hearing, balance, and vision in the fetus. There are no controlled data in human pregnancy. Chloroquine can be prescribed for either prevention or treatment of malaria. Chloroquine can be prescribed to adults and children of all ages. It can also be safely taken by pregnant women and nursing mothers. Malaria infection during pregnancy can lead to miscarriage, premature delivery, low birth weight, congenital infection, and/or perinatal death. Pregnant women are three times more likely to develop severe disease than non-pregnant women acquiring infections from the same area. Pregnant women and chloroquine Antimalarial Drugs During pPregnancy –, Hydroxychloroquine Use During Pregnancy Plaquenil causes skin rashHydroxychloroquine retinopathy screening Antimalarial drugs and pregnancy safety, pharmacokinetics, and pharmacovigilance Stephen A Ward, Esperanca J P Sevene, Ian M Hastings, François Nosten, Rose McGready. studies in which chloroquine has been used in pregnancy. over 2000 pregnant women treated with the drug in the Antimalarial drugs and pregnancy safety, pharmacokinetics.. FDA Urged to Approve Chloroquine to Treat COVID-19. Repurposing of the anti-malaria drug chloroquine for Zika.. Chloroquine phosphate is a 4-aminoquinolone that acts by inhibiting heme polymerase. 198 Chloroquine is well tolerated and in appropriate doses may be safely used by young children and pregnant women. 199 Transient nausea or vomiting is seen in a small proportion of individuals and may usually be reduced by taking the drug with food. Occasionally, headaches or blurred vision are reported. Anti-malarial drugs hydroxychloroquine, chloroquine are considered pregnancy category C drugs. While there is evidence of risk for damage to the eye and ear, if the benefits of these drugs in controlling RA symptoms are judged to outweigh the risks, they may continue to be used during pregnancy. 1,2 Chloroquine is also used for prophylaxis for pregnant women and non-immune individuals at risk. Dosage and administration. All dosages are described in terms of the base. Treatment. Oral administration. To avoid nausea and vomiting chloroquine should be administered after meals.