Hydroxychloroquine retinopathy risk factors

Discussion in 'Chloroquine Phosphate' started by MAKC, 09-Mar-2020.

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    Hydroxychloroquine retinopathy risk factors


    This eye toxicity limits long-term use of the drugs. The risk of toxicity is low for individuals without complicating conditions during the first 5 years of treatment using less than 6.5 mg/kg/day of hydroxychloroquine or 3 mg/kg/day of chloroquine, and/or cumulative doses of less than 1000 gram and 460 gram (total dose), respectively.

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    Over 80 % of patients taking 4-aminoquinolines 4AQs have risk factors for retinopathy. The most important risk factor is the adjusted daily dose. Taking hydroxychloroquine at a dose less than 6.5 mg/kg/d based on the lesser of actual and ideal body weight is typically safe. Abstract. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Chloroquine retinopathy, is a form of toxic retinopathy damage of the retina caused by the drugs chloroquine or hydroxychloroquine, which are sometimes used in the treatment of autoimmune disorders such as rheumatoid arthritis and systemic lupus eye toxicity limits long-term use of the drugs.

    The earliest signs of toxicity include bilateral paracentral visual field changes (best detected with a red test object) and a subtle granular depigmentation of the paracentral RPE. Some physicians suggest that lean body weight is more accurate when calculating daily dosage.

    Hydroxychloroquine retinopathy risk factors

    IMPROVING THE RISK-BENEFIT. - PubMed Central PMC, Recommendations on Screening for Chloroquine and Hydroxychloroquine.

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  6. Major risk factors for hydroxychloroquine-induced retinopathy include a cumulative dose of more than 1000 g, 3 a daily dose of more than 6.5 mg/kg, 3 duration of treatment longer than five years, 9 development of age-related changes to the eye, 10 pre-existing retinopathy, 7 kidney or liver disease, 4 and concurrent use of tamoxifen. 4

    • Hydroxychloroquine-induced retinopathy in a 57-year-old woman.
    • Chloroquine retinopathy - Wikipedia.
    • Revised Recommendations on Screening for Chloroquine and..

    Risk factors. Major risk factors for hydroxychloroquine-induced retinopathy include a cumulative dose of more than 1000 g,3 a daily dose of more than 6.5 mg/kg,3 duration of treatment longer than five years,9 development of age-related changes to the eye,10 pre-existing retinopathy, 7 kidney or liver disease,4 and concurrent use of tamoxifen.4 It is recognized, however, that retinal toxicity is occasionally seen in apparently low-risk individuals, inviting the possibility that there may be genetic or other as yet unrecognized risk factors or alternative causes of retinopathy, as these can be hard to distinguish clinically, especially in early stages. The survey focused on physician's hydroxychloroquine screening practices and their knowledge of risk factors for developing hydroxychloroquine retinopathy. Following institutional review board approval, survey results were compared with the PPP guidelines.

     
  7. nykkyvr Guest

    Chloroquine has long been used in the treatment or prevention of malaria from Plasmodium vivax, P. malariae, excluding the malaria parasite Plasmodium falciparum, for it started to develop widespread resistance to it. Hydroxychloroquine - Side Effects, Dosage, Interactions. Chloroquine - brand name list from Hydroxychloroquine
     
  8. Pavel_os Well-Known Member

    Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Atovaquone-Proguanil versus Chloroquine-Proguanil for Malaria. Boots Chloroquine and Proguanil Anti-Malarial Tablets. Chloroquine - LiverTox - NCBI Bookshelf
     
  9. Forexland New Member

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