In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio. Does chloroquine increase or decrease cell viability Chloroquine disadvantages Is plaquenil a blood thinner Plaquenil indication Focus on Eyes Long-term Plaquenil intake can affect your vision by Dr. Juan Carlos de Rivero Vaccari and Dr. Frederick Ho, Special to FLORIDA TODAY Plaquenil, or hydroxychloroquine, is an anti-malaria medication that is commonly used to treat autoimmune disorders. Because the patient has previous macular pathology, should we make a recommendation to stop the Plaquenil? It’s an important question to address, because pre-existing macular pathology is a risk factor for the development of retinal toxicity according to the new screening recommendations. Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. It is now considered for new disease applications in diabetes, heart disease and adjunct cancer therapies 2. As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits. Plaquenil treatment with macular degeneration Conditions Plaquenil-related Eye Problems Eugene Eye Care, Pause the Plaquenil? Is plaquenil retinal toxicity reversibleSymptoms of plaquenil toxicityTreatment chloroquine resistant malaria If you have any questions or want more information about any drug on this list and its possible links to macular degeneration, talk to your prescribing physician and/or ophthalmologist. You may also want to discuss whether the use of a drug on this list outweighs the increased risk of side effects compared with other treatments. Medication Cautions in Macular Degeneration - AMDF. Hydroxychloroquine Plaquenil Toxicity and.. Hydroxychloroquine-Induced Retinal Toxicity - American.. Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. The major macular disease which we know more about is age-related macular degeneration ARMD for which the NIH has guideline to help protect the macula including oral supplements of lutein and zeaxanthin. It is not known whether this would benefit patients on HCQ or those with toxicity. Macular Society is the trading name of the Macular Disease Society. A charity registered in England and Wales 1001198, Scotland SC042015. 1123 Isle of Man. A company limited by guarantee, registered in England No. 2177039.