An audit of 100 patients seen at any of nine Canadian rheumatology clinics during early 2016 showed that 30% of patients were not on appropriate weight-based hydroxychloroquine dosages, and 13% of patients on the drug had not received a baseline retinal assessment during their first year of treatment, “We are significantly below the standard of care for appropriately dosing and screening” patients treated with hydroxychloroquine (Plaquenil), concluded Dr. Koppikar, an internal medicine physician at Queens University in Kingston, Ont. Plaquenil myositis Plaquenil irritability Hydroxychloroquine Plaquenil is considered a disease-modifying anti-rheumatic drug DMARD. It can decrease the pain and swelling of arthritis. It may prevent joint damage and reduce the risk of long-term disability. Hydroxychloroquine is in a class of medications that was first used to prevent and treat malaria. Of note, however, although the average daily dose of hydroxychloroquine was comparable for those who had not developed renal damage than for those who had developed it, the maximum average dose was higher in the first than in the second group, again supporting its protective role. Some limitations of our study are worth noting. PLAQUENIL prescription and dosage sizes information for physicians and healthcare professionals. Pharmacology, adverse reactions, warnings and side effects. Although his study did not examine reasons for the compliance shortfall, Dr. HCQ comes only as 200-mg tablets, and prescribing intermediate dosages can be a challenge (although veteran clinicians know that a safe and easy way to dial down a dosage is to have the patient periodically skip a dose). In a second recently reported study, researchers from the Chicago area documented that roughly half of the 554 rheumatology patients on hydroxychloroquine (HCQ) in a regional health system and seen by an ophthalmologist during 2009-2016 received an excessive dosage of the drug (). Hydroxychloroquine renal dosing The Role of Hydroxychloroquine Blood Levels in SLE RheumNow., Protective Effect of Hydroxychloroquine on Renal Damage in. Chloroquine phosphate invertsIs chloroquine sulfonamides Hydroxychloroquine is used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America. Hydroxychloroquine - Side Effects, Dosage, Interactions - Drugs.. PLAQUENIL Dosage & Rx Info Uses, Side Effects. Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria. A risk factor for Plaquenil hydroxychloroquine retinotoxicity is a daily dose that exceeds 5.0 mg of drug per kg of body weight. The tool on the right simply calculates this threshold based on a ppatient’s real body weight. It’s important to understand that the daily dose is only one risk factor for plaquenil retinotoxicity. Risk factors that increase the chance of hydroxychloroquine retinopathy include daily dosage, cumulative dose, renal or liver disease, age, and previous retinal disease 9. A daily dose of 6.5mg/kg ideal body weight places patients at higher risk, but a daily dose below this level did not preclude the patient from developing toxicity after. Typical starting dose is 800 mg. This is followed by 400 mg three times 6 hours after the first dose, 24 hours after the first dose, and 48 hours after the first dose.