Chloroquine diphosphate lysosome

Discussion in 'Chloroquine Drug' started by Mnimis, 12-Mar-2020.

  1. Legionn Guest

    Chloroquine diphosphate lysosome


    Chloroquine has been extensively used in mass drug administrations, which may have contributed to the emergence and spread of resistance. It is recommended to check if chloroquine is still effective in the region prior to using it.

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    Chloroquine is a member of quinolone family and is a weak intercalating agent. Chloroquine is used for treating amebiasis, rheumatoid arthritis, discoid and systemic lupus erythematosus. Application DNA intercalator. Also used to increase transfection efficiency. Chloroquine diphosphate salt has been used • in in vitro antiplasmodial assays Chloroquine is commonly used to study the role of endosomal acidification in cellular processes 2, 3, such as the signaling of intracellular TLRs. Moreover, Chloroquine inhibits autophagy as it raises the lysosomal pH, which leads to inhibition of both fusion of autophagosome with lysosome and lysosomal protein degradation 4. Chloroquine overdose is a life-threatening emergency and should be managed with cardio-respiratory and hemodynamic support, monitoring of potassium along with management of arrhythmias and convulsions, as necessary. A patient who survives the acute phase and is asymptomatic should be closely observed until all clinical features of toxicity resolve.

    The Centers for Disease Control and Prevention recommend against treatment of malaria with chloroquine alone due to more effective combinations. In areas where resistance is present, other antimalarials, such as mefloquine or atovaquone, may be used instead.

    Chloroquine diphosphate lysosome

    Chloroquine - FDA prescribing information, side effects and uses, Chloroquine for research Cell-culture tested InvivoGen

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  7. Research studies demonstrate that chloroquine accumulates in acidic lysosomes and increases the lysosomal pH. This inhibits lysosomal hydrolases and prevents autophagosomal fusion and degradation, which can result in apoptotic or necrotic cell death 1-4.

    • CST - Chloroquine.
    • Chloroquine - FDA prescribing information, side effects..
    • Chloroquine Sigma-Aldrich.

    A severe eye problem has happened with chloroquine. This may lead to lasting eyesight problems. The risk may be higher if you have some types of eye or kidney problems. The risk may also be higher with some doses of chloroquine, if you use chloroquine for longer than 5 years, or if you take certain other drugs like tamoxifen. Chloroquine is an inhibitor of the lysosomal degradation of the DNA which is taken up by the cells, so as leelee said, transfection should have been successful, albeit at a slightly lower level than if you would have added the chloroquine. In my normal transfections, I never add chloroquine and get high efficiencies nevertheless. Several lysosomal inhibitors such as bafilomycin A1 BafA1, protease inhibitors and chloroquine CQ, have been used interchangeably to block autophagy in in vitro experiments assuming that they all primarily block lysosomal degradation.

     
  8. pornobaron Moderator

    Hydroxychloroquine (Plaquenil) is considered a disease-modifying anti-rheumatic drug (DMARD). PLAQUENIL HYDROXYCHLOROQUINE SULFATE TABLETS, USP DESCRIPTION Hydroxychloroquine Plaquenil Dosing Calculator - MDCalc Hydroxychloroquine - Wikipedia
     
  9. iagupop77 Well-Known Member

    I've been taking Plaquenil 400 mg for nearly 6 mos. Treating Lupus with Anti-Malarial Drugs Johns Hopkins. Common Medications That Cause Joint Pain, From Cholesterol. Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses
     
  10. Net_Prosto User

    Generic Plaquenil Availability - Generic Plaquenil Availability. Plaquenil is a brand name of hydroxychloroquine, approved by the FDA in the following formulations PLAQUENIL hydroxychloroquine sulfate - tablet;oral Manufacturer CONCORDIA Approved Prior to Jan 1, 1982 Strengths 200MG ; Has a generic version of Plaquenil been approved?

    What is Hydroxychloroquine? - GoodRx
     
  11. Shuher800 Moderator

    Hydroxychloroquine Prices, Coupons & Patient Assistance. The cost for hydroxychloroquine oral tablet 200 mg is around for a supply of 50, depending on the pharmacy you visit. Prices are for cash paying customers only and are not valid with insurance plans.

    Plaquenil Prices, Coupons & Savings Tips - GoodRx