I don't get many side effects generally, but with prednisone I DO. It does help, but this can't be a long term affair. Plaquenil is a great drug (I have no experience with it, but many people with lupus take it). I'd ask your rheumy about it and have them explain why they made that choice for you. Prednisone is an intermediate acting corticosteroid-which means it has direct anti-inflamitory properties that take effect begining in a few hours. Is plaquenil another option instead of the prednisone? It is ment to get this undercontrol now and diminish your pain. Chloroquine malaria treatment Chloroquine fluorescence spectrum Order aralen medication Reticulocytes chloroquine They wanted me to go on steroids, but I have a really bad reaction with them, so now I don't know if there is anything I can be given to control my MCTD. Does anyone know if there is any other treatments or meds that have worked for you if you can't take Plaquenil or steroids? If you miss a dose, take it as soon as you remember. If it is very near the time of the next dose, skip the missed dose and continue with your normal dosing schedule. Do not double dose at one time to catch up. Plaquenil should be stored away from light and moisture and at room temperature up to 86 degrees F 30 degrees C. So she is having me start sulfasalazine---- do any of you take this and even better do any of you take this along with plaquenil and/or prednisone because until I can wean myself off the awful prednisone I will be taking all three medicines. It has not direct anti-inflamitory properties and instead works on the immune system-though the mechanism is not known. Plaq is a longer time medication it may take two months before their is a noticable difference. Should you take plaquenil with steroids Plaquenil Oral Interactions with Other Medication, Plaquenil What You Need to Know - Kaleidoscope Fighting Lupus Plaquenil icd 9Is coughing normal when taking plaquenil Interactions between your drugs. There were no interactions found in our database between Plaquenil and prednisone - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist. . Taking plaquenil and sulfasalazine Arthritis Information. The Risk of Retinal Toxicity with Plaquenil - Sjogren's. The prednisone is a steriod and the plaquenil is a anti malaria drug. The thing with plaquenil for me is that I don't notice much of anything taking it but when I go off then I flare up and then really notice it. I have been taking the plaquinil for about 8 years morning and night and the prednisone off and on. Yes, if the plaquenil controls your Lupus flares, it is best to not use the prednisone. I hope you can get off of it completely, or at least take a small maintenance dose. Take it very slow, tapering off, and if you have a reaction, severe fatigue, etc, talk to your doc, about tapering down even slower. Do not abruptly stop taking steroids. You should not stop taking steroids abruptly if you have been taking them for more than 4 weeks. Once your body has adjusted to taking steroids, your adrenal glands may shrink and produce less natural cortisone.