Plaquenil half-life

Discussion in 'Chloroquine 250' started by necro2000, 03-Mar-2020.

  1. Toxic_Cat Moderator

    Plaquenil half-life


    Hi Dr V, I am at a crossroad of considering to go back on Plaquenil . A year ago I proposed to go off Plaquenil after being on it for 22 years.

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    Jan 03, 2020 Pharmacokinetics Following a single 200 mg oral dose of PLAQUENIL to healthy male volunteers, the mean peak blood concentration of hydroxychloroquine was 129.6 ng/mL, reached in 3.26 hours with a half-life of 537 hours 22.4 days. Hydroxychloroquine HCQ, sold under the brand name Plaquenil among others, is a medication used for the prevention and treatment of certain types of malaria. Specifically it is used for chloroquine-sensitive malaria. Other uses include treatment of rheumatoid arthritis, lupus, and porphyria cutanea tarda. It is taken by mouth. I tend to agree with you 100%. I have not stopped completely itiching yet and I know Plaquenil has a long half life. I notice after showering in the morning it seems to stimulate the itching even more. It did not last as long this morning though. I will think twice before taking it again.

    If I had joint or muscle aches, I took care of it by resting, Aleve and ice. At my recent eye exam the doctor mentioned I had reached the plaquenil toxicity level and that my retina cells could die (which do not regenerate! My proposal was based on the fact that I had not had any major inflamation that completely shut me down or keep me from being active.

    Plaquenil half-life

    Lupus Medicines Hydroxychloroquine - Brigham and Women's Hospital, Hydroxychloroquine - Wikipedia

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    So, I've read the half-life is from 30-60 days. That is one of the reasons I didn't want to take it - that's a long time to stick around. I did read hair loss, photosensitivity, itching area all potential side effects of Plaquenil, so hopefully those will subside soon as the med levels drop. Plaquenil is very effective for the symptoms of achiness and fatigue. However, there might be a price to pay in terms of retinal toxicity especially after taking it for as long as you have. Given that the alopecia had developed while you were on the plaquenil, it's not clear that going back on it will help that symptom much. Abstract. 1. Five healthy volunteers received, in a randomised crossover design study, a 155 mg oral tablet and an intravenous infusion of 155 mg racemic hydroxychloroquine 200 mg hydroxychloroquine sulphate to assess the bioavailability of the commercially available tablet Plaquenil, Winthrop Laboratories, Australia.

     
  4. Sanchos Well-Known Member

    Since being diagnosed with Lupus and taking the normal meds, particularly Plaquenil and Prednisone (over about 6 years), I gained about 45 pounds. Hair loss and Plaquenil? DailyStrength Plaquenil & Weight Gain/Loss - Common and Rare Side Effects for Plaquenil Oral
     
  5. motorin Well-Known Member

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