While the exact percentage of RA patients who experience sleep problems is hard to nail down, more than 80% of people with RA report fatigue as part of their symptoms. Why Sleep Matters Sleep problems can increase levels of stress hormones and aggravate flares, says Rochelle Rosian, MD, a Cleveland Clinic rheumatologist. Hydroxychloroquine pulmonary fibrosis Chloroquine storage conditions Some medications, such as prednisone and hydroxychloroquine, also have the side effect of causing sleeplessness. It is a good idea to take these drugs earlier in the day to reduce this effect. Glucosamine and chondroitin. These are dietary supplements used to improve joint function by treating pain and inflammations. Although both are naturally occurring within the human body, studies have linked excessive levels to gastrointestinal side effects as well as insomnia. PLAQUENIL is a synthetic Quinilone, belongs in the Floro Quinilone family which has a black box warning by the FDA. I did not this at the time i took it. Previously had bad tendon damage with Cipro. “When you sleep, you make all those brain chemicals that you need to feel better. And even if you’re not flaring, you may not manage your pain as well if you’re not sleeping. Plaquenil and insomnia Lupus-Induced Insomnia and a Feeling of Isolation, Types of Medication Known To Cause Insomnia and Nightmares. Chloroquine syrupWhat is hydroxychloroquinChloroquine drug cardWhat is blood test for plaquenil liver damage Plaquenil gave me anxiety and I could not sleep while taking a higher dose. You should probably call your doctor and tell them. Maybe they can adjust your milligrams to a lower dose to see if that is what is causing the insomnia. It is no fun not to be able to sleep, i hope you get this figured out and get some rest - Insomnia and Plaquenil? - Sjogren's World. PLAQUENIL Side Effects, Reviews by Patients -. Insomnia because of plaquenil DailyStrength. Medical usesHistorySide effectsMechanism of actionResultsAdministrationRisksDiagnosisInteractionsPreventionBenefits Some common RA medications may also contribute to sleeplessness. One is the steroid prednisone, which can cause insomnia, agitation or depression. Taking it earlier in the day is best, says Dr. Rosian. Another is hydroxychloroquine Plaquenil. It can sometimes causes people to get jumpy, nervous and twitchy. Fragmented Sleep Hydroxychloroquine, a derivative of chloroquine, is frequently used as the first-line treatment, and it always results in rapid improvement within about a month of starting the treatment; however, recurrence is also common 5. The present patient responded well to hydroxychloroquine. Unfortunately, he had hypomnesis after administrated the drug.