It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Do the side effects of plaquenil go away Plaquenil 200 Can you stop Plaquenil cold turkey" answer - YES. My rheumy told me to take time out on it for a month once. I really don't know why because he only told me to do it the once and I've been on it for six years now He said to give the system a rest for a moth and siad in his experience the disease seemed to be less active in January - so to do. I have had to stop my plaquenil and aside from the fatigue and joint pain that I knew I would have, I also now have a sunburned look on my face when I go out in the sun and itching skin, almost like a hive type rash on my back. Plaquenil is prescribed as a disease-modifier, in other words, to decrease pain, decrease swelling, and prevent joint damage and disability. It is not known how Plaquenil works but researchers believe that Plaquenil interferes with communication between cells within the immune system. Ultimately, it is thought to block proinflammatory. Hydroxychloroquine comes as a tablet to take by mouth. This medication is sometimes prescribed for other uses; ask your doctor or pharmacist for more information. Stopping plaquenil abruptly What happens if you stop taking methotrexate suddenly., Discontinued Plaquenil.itching skin? Chloroquine inhibits autophagic flux by decreasing autophagosome-lysosome fusionPlaquenil dermatomyositisNormal dosage of plaquenil Plaquenil’s long half-life in the body can cause irreversible and progressive damage, Dr. Fung said. Similarly, one study reported that 16 women who’d taken hydroxychloroquine or chloroquine, or a combination of the agents, showed no improvement seven years after stopping drug therapy, and progression occurred in six of the cases. 2 Rx Side Effects New Plaquenil Guidelines and More.. Taking Plaquenil for Rheumatoid Arthritis. Hydroxychloroquine Oral Route Description and Brand Names - Mayo Clinic. Your infection may not clear up if you stop using the medicine too soon. For patients taking hydroxychloroquine to prevent malaria Your doctor may want you to start taking this medicine 1 to 2 weeks before you travel to an area where there is a chance of getting malaria. If plaquinil is the cause of muscle twitching/weakness if dr takes me off of it will muscle twitching stop? Why does plaquenil hydroxychloroquine cause thisis it serious; My dr said 2 stop plaquenil hydroxychloroquine to see if tremors are from it barly visable tremors & irritability if I stop how long till tremor go away if its plaquin? I was just curious if i was to try plaquenil again for a few days/weeks if you decide to stop do you have to wean off like a lot of drugs or can you simply stop taking it.thanks.