One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. Will my hair grow back after plaquenil Plaquenil related to insomnia Sep 15, 2014 Hydroxychloroquine sulfate HCQ, Plaquenil is an analogue of chloroquine CQ, an antimalarial agent, used for the treatment of systemic lupus erythematosus, rheumatoid arthritis and other autoimmune disorders. Its use has been associated with severe retinal toxicity, requiring a discontinuation of therapy. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1%. Research into the wide-ranging effects of hydroxychloroquine has revealed many important benefits in the treatment of lupus; it must be noted that these benefits may be less effective in people who smoke Arthritis Care & Research 2010; 3–400. Benefits include Decrease in the number of disease flares. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Plaquenil renal toxicity Drug Toxicity to the Retina and Optic Nerve Are You., How to Succeed in Plaquenil Screenings Plaquenil and psychosis Hydroxychloroquine Toxicity Screening Is Key. Hydroxychloroquine Plaquenil is a disease-modifying antirheumatic drug that is commonly used to reduce arthritic pain and swelling. Signs and symptoms. “The association of Plaquenil therapy with macular toxicity is well established,” said Michael F. Marmor, MD, at the Byers Eye Institute at Stanford University. Drug Toxicity to the Retina and Optic Nerve Are You Missing.. Drug spotlight on hydroxychloroquine Lupus Foundation of.. Plaquenil - FDA prescribing information, side effects and uses. Monitor patients for cardiomyopathy during PLAQUENIL therapy. Chronic toxicity should be considered when conduction disorders bundle branch block/atrio-ventricular heart block or biventricular. PLAQUENIL with drugs known to induce retinal toxicity, such as tamoxifen, is not recommended. Careful ophthalmologic examination should be more frequent and adapted to the patient, in the Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1is now considered for new disease applications in diabetes, heart disease and adjunct.