Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight. Plaquenil with zyban Do chloroquine cause splenomegaly More energy on plaquenil If abnormalities are present only unilaterally, investigate other causes besides hydroxychloroquine toxicity see “Differential Diagnosis of Bull’s-Eye Maculopathy”. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools. Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight. Management of plaquenil maculopathy Hydroxychloroquine retinopathy A review of imaging, Chloroquine and Hydroxychloroquine Toxicity Treatment. Why would plaquenil not work on raChloroquine santa cruzCan hydroxychloroquine cause depressionPlaquenil liver toxicityWhat is in hydroxychloroquine Besides Plaquenil and Chloroquine, what other drug is known to cause Bull's eye Maculopathy? HVF 24-2 or 30-2 instead of 10-2 because damage tends to be further from the fovea Do SD-OCT scans outside of fovea too- FAF is a good choice Ocular Side effects of Oral Medications Flashcards Quizlet. Recommendations on Screening for Chloroquine and.. Eye screening for patients taking hydroxychloroquine Plaquenil. These medications are initially used in the prophylaxis and treatment of malaria. Plaquenil has replaced chloroquine because it produces less retinal side effects. Aside from its initial intended use, it has been also used for the management of rheumatoid arthritis, systemic lupus erythematosus and several other connective tissue disorders 1. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Management of Patients with Definite Toxicity Criteria Level of evidence A recommendation to stop hydroxychloroquine should be made to the prescribing physician to facilitate further discussion between specialist for the treatment indication and patient about the risk of stopping hydroxychloroquine and the options for alternative drug therapy.