Management of plaquenil maculopathy

Discussion in 'Canadian Pharmaceuticals Online' started by Bobroid, 14-Mar-2020.

  1. Niger_xp New Member

    Management of plaquenil maculopathy


    Pattern of Retinopathy: Although the locus of toxic damage is parafoveal in many eyes, Asian patients often show an extramacular pattern of damage. Dose: We recommend a maximum daily HCQ use of 5.0 mg/kg real weight, which correlates better with risk than ideal weight.

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    If abnormalities are present only unilaterally, investigate other causes besides hydroxychloroquine toxicity see “Differential Diagnosis of Bull’s-Eye Maculopathy”. Mechanism of Toxicity. The mechanism of hydroxychloroquine retinal toxicity has yet to be fully elucidated. Chloroquine and hydroxychloroquine belong to the quinolone family. They are related drugs with similar clinical indications for use and similar manifestations of retinal toxicity, although their therapeutic and toxic doses differ. Background The American Academy of Ophthalmology recommendations on screening for chloroquine CQ and hydroxychloroquine HCQ retinopathy are revised in light of new information about the prevalence of toxicity, risk factors, fundus distribution, and effectiveness of screening tools.

    Risk of Toxicity: The risk of toxicity is dependent on daily dose and duration of use. There are no similar demographic data for CQ, but dose comparisons in older literature suggest using 2.3 mg/kg real weight.

    Management of plaquenil maculopathy

    Hydroxychloroquine retinopathy A review of imaging, Chloroquine and Hydroxychloroquine Toxicity Treatment.

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  7. Besides Plaquenil and Chloroquine, what other drug is known to cause Bull's eye Maculopathy? HVF 24-2 or 30-2 instead of 10-2 because damage tends to be further from the fovea Do SD-OCT scans outside of fovea too- FAF is a good choice

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    These medications are initially used in the prophylaxis and treatment of malaria. Plaquenil has replaced chloroquine because it produces less retinal side effects. Aside from its initial intended use, it has been also used for the management of rheumatoid arthritis, systemic lupus erythematosus and several other connective tissue disorders 1. Toxic maculopathy associated with chloroquine use was first documented in the literature five decades ago.1 In the United States, Plaquenil––an analog to chloroquine––is used to treat a variety of conditions, including rheumatoid arthritis, lupus and several distinct inflammatory disorders. Management of Patients with Definite Toxicity Criteria Level of evidence A recommendation to stop hydroxychloroquine should be made to the prescribing physician to facilitate further discussion between specialist for the treatment indication and patient about the risk of stopping hydroxychloroquine and the options for alternative drug therapy.

     
  8. OlegSurf User

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. RA and Hydroxychloroquine How Effective is it for. Plaquenil Dosage Guide - RA and Hydroxychloroquine How Effective is it for Rheumatoid Arthritis.
     
  9. Raintime User

    This is not a list of all drugs or health problems that interact with chloroquine. Chloroquine - Wikipedia INVESTIGATION Eleven years after ban, Chloroquine still. Chloroquine C18H26ClN3 - PubChem
     
  10. Anafay XenForo Moderator

    Inhibition of autophagy with bafilomycin and chloroquine. Effects of bafilomycin and chloroquine on autophagy and cell survival. Primary rat cortical neurons at DIV7 were used for experiments. A-D Western blot analyses of LC3-I and LC3-II in lysates in neurons exposed to increasing concentrations of bafilomycin baf or chloroquine CQ for 24 h.

    Autophagy Assays Sigma-Aldrich