Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine: Incidence not known Some side effects of hydroxychloroquine may occur that usually do not need medical attention. Does plaquenil cause tinnitus What is hydroxychloroquine made of Dr shehata hydroxychloroquine Chloroquine phosphate over the counter That is a good suggestion! i'll call them up and see- could split dose between breakfast and lunch or take all in the morning. Continue this thread level 1. 2 points 3 years ago. Have been on Plaquenil for 11 years and have never had issues with sleepwalking-- or any other issues. I would definitely bring this up with your rheumy and see. Hydroxychloroquine and Plaquenil are the same. Plaquenil is the brand name and hhydroxychloroquine is the generic. My rheumatologist thought the brand name was purer and less apt to cause problems and, in fact, I've had no side effect from it. However, I have an eye doctor's appt this Friday and hopefully it will have had any effect on my eyes. Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. These side effects may go away during treatment as your body adjusts to the medicine. Splitting hydroxychloroquine Side Effects of Plaquenil Hydroxychloroquine, Warnings, Uses, Breaking pills in half hydrochloroquine/plaquinil? - LUPUS UK Hydroxychloroquine effects on blood sugarHistory of chloroquine resistance Aug 30, 2011 Diagnosis Hydroxychloroquine-induced retinal toxicity Discussion. Chloroquine CQ and hydroxychloroquine Plaquenil HCQ have been used for many years, initially for the treatment of malaria but now more commonly for the treatment of inflammatory diseases such as rheumatoid arthritis and lupus 1. Hydroxychloroquine Plaquenil Toxicity and Recommendations.. Hydroxychloroquine MedlinePlus Drug Information. Hydroxychloroquine Oral Route Proper Use - Mayo Clinic. Don’t split your pills with a knife. Studies show that doing so too often leads to unequal halves. Pills should only be split in half, not into smaller portions, such as thirds or quarters. The easiest pills to split are relatively flat round ones with a scored center. Urine hydroxychloroquine levels were still detectable after 3 months with approximately 10% of the dose excreted as the parent drug. Results following a single dose of a 200 mg tablet versus i.v. infusion 155 mg, demonstrated a half-life of about 40 days and a large volume of distribution. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking hydroxychloroquine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes.