One such commonly used medication for dermatologic and rheumatologic inflammatory conditions is hydroxychloroquine (Plaquenil), a chloroquine derivative. It is used to treat many diseases including malaria, rheumatoid arthritis and systemic lupus erythematosus. What does plaquenil do to the eyes Novo-chloroquine 250 mg side effects Jun 30, 2015 Take this medication with a meal or a glass of milk to prevent stomach upset. Common side effects include nausea, loss of appetite, headache, and diarrhea. Plaquenil can cause blurred vision and dizziness. Do not drive or operate heavy machinery until you know how it affects you. Effects of a Plaquenil overdose may include, but are not limited to Headaches. Drowsiness. Vision changes. Seizures. Cardiac arrest. An irregular heart rhythm arrhythmia. Loss of life. Clinical monitoring for signs and symptoms of cardiomyopathy is advised, including use of appropriate diagnostic tools such as ECG to monitor patients for cardiomyopathy during Plaquenil therapy. Chronic toxicity should be considered when conduction disorders bundle branch block/atrio-ventricular heart block or biventricular hypertrophy are. It is imperative that patients and physicians are aware of and watch for this drug’s ocular side effects. Retinal toxicity from hydroxychloroquine is rare, but even if the medication is discontinued, vision loss may be irreversible and may continue to progress. Signs of plaquenil overdose Despite Plaquenil dosing recommendations, retinal toxicity., Plaquenil Overdose - Antibiotics Home Page Plaquenil toxicity guidelineEye toxicity hydroxychloroquine Mar 15, 2019 Published March 15, 2019 Spotting the Telltale Signs of Plaquenil Toxicity Subtle but characteristic alterations on OCT are often your first clue. RO Staff Spotting the Telltale Signs of Plaquenil Toxicity. Plaquenil - FDA prescribing information, side effects and uses. Hydroxychloroquine-Induced Retinal Toxicity - American.. Plaquenil toxicity is typically asymptomatic in early stages, but over time can lead to severe vision loss and retinal damage. The risk of retinal toxicity was initially believed to be less than 1%. Feb 19, 2020 Call your doctor at once if you have headache with chest pain and severe dizziness, fainting, fast or pounding heartbeats; very slow heart rate, weak pulse; muscle weakness, numbness or tingling; low blood sugar --headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate. Aug 29, 2014 The side effect that is of greatest concern is retinal toxicity. Retinal toxicity of Plaquenil may manifest itself with subtle disturbances of the retinal pigment epithelium which may eventually lead to complete destruction of the macula in the form of bull’s-eye maculopathy.