Malaria parasites can enter the body through these mosquito bites, and then live in body tissues such as red blood cells or the liver. This medication is used to kill the malaria parasites living inside red blood cells. Gene rdh12 chloroquine retinopathy Eye damage from plaquenil Synthesis procedure of chloroquine Chloroquine is the generic form of the brand-name prescription medicine Aralen, which is used to prevent and treat malaria — a mosquito-borne disease caused by a parasite — and to treat amebiasis, an infection of the intestines caused by a parasite. Background/Purpose Chloroquine CQ and Hydroxychloroquine HCQ have been used for years during pregnancy for multiple indications malaria prevention, autoimmune disorders, etc. Recently, some countries face restrictions to prescribe these drugs during pregnancy, due to report of ocular toxicity in animal models and potential genotoxicity. Chloroquine–proguanil While chloroquine and proguanil are both safe in pregnancy, the combination is ineffective in preventing chloroquine-resistant malaria and is not recommended. Both drugs may be needed for a complete cure and to prevent the return of infection (relapse). In some cases, you may need to take a different medication (such as primaquine) to kill the malaria parasites living in other body tissues. Chloroquine and proguanil during pregnancy Can I take anti-malaria medication if I'm pregnant? - NHS, Safety of Chloroquine and Hydroxychloroquine During Pregnancy. Hydroxychloroquine safe while breastfeedingHydroxychloroquine and leflunomide togetherHow does hydroxychloroquine help lupusPlaquenil poisoning Chloroquine and proguanil are safe during all trimesters and can be given in usual doses in areas where P. falciparum strains are sensitive. If proguanil is used, prescribe folic acid 5 mg daily. Mefloquine is suitable in the second and third trimesters; in the first trimester lack of safety data concerning miscarriages suggests that caution should be exerted before prescribing. Malaria Prophylaxis. The ABCD of Malaria Prophylaxis.. Chapter 5.2 - Malaria issues in special hosts - pregnancy and.. Atovaquone-Proguanil versus Chloroquine-Proguanil for Malaria.. Oct 14, 2012 Rates of spontaneous abortion and birth defects were comparable in pregnant women taking mefloquine, compared with chloroquine-proguanil, or pyrimethamine-sulfadoxine prophylaxis, in the first trimester of pregnancy. Jul 23, 2014 Chloroquine and proguanil are safe during all trimesters and can be given in usual doses in areas where P. falciparum strains are sensitive. If proguanil is used, prescribe folic acid 5 mg daily. Mefloquine is suitable in the second and third trimesters; in the first trimester lack of safety data concerning miscarriages suggests that caution should be exerted before prescribing. Malaria infection during pregnancy has however, been shown to increase the risk of miscarriage. Can taking proguanil in pregnancy cause my baby to be born with birth defects? A baby’s body and most internal organs are formed during the first 12 weeks of pregnancy. It is mainly during this time that some medicines are known to cause birth defects.