Chloroquine major issue

Discussion in 'Canada Pharmaceuticals Online' started by MotorTrend, 26-Feb-2020.

  1. Chloroquine major issue


    It is similar to CQ in practically any way, although its similar efficacy against COVID-19 would still be an assumption. So far I have found these: There are about 10 clinical trials in China looking at hydroxychloroquine for COVID, including some comparing it with chloroquine phosphate.

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    In vitro chloroquine and its analog hydroxychloroquine are endowed with broad‐spectrum anti‐HIV‐1 and HIV‐2 activity at clinically achievable concentrations 0–12.5 μmol/L Savarino et al. 2001a. Chloroquine also inhibits HIV‐1 in post‐integrational event by affecting newly produced viral envelope glycoproteins. Both chloroquine and hydroxychloroquine are used off-label for rheumatoid arthritis and for lupus, but how they work in these areas is another shoulder-shrugger, and there are side effects in the eye. It’s been suggested as an adjunct in some cancer therapy regimes, but there are problems there, too, in the kidney. Co-administration of chloroquine and mefloquine may increase the risk of convulsions. The blood concentrations of chloroquine and desethylchloroquine the major metabolite of chloroquine, which also has antimalarial properties were negatively associated with log antibody titers.

    You can search the Chinese clinical trial database here (type "hydroxychloroquine" into the Public Title field): HCQ prevents dengue virus infection in vitro. Don't worry, the studies are being done and the data will be out soon.

    Chloroquine major issue

    Chloroquine Indications, Side Effects, Warnings -, Chloroquine, Past and Present In the Pipeline

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  4. Aralen Chloroquine may treat, side effects, dosage, drug interactions, warnings, patient labeling, reviews, and related medications including drug comparison and health resources. the major metabolite of chloroquine, which also has antimalarial properties. Report Problems to the Food and Drug Administration.

    • Aralen Chloroquine Uses, Dosage, Side Effects..
    • Aralen Chloroquine Uses, Dosage, Side Effects, Interactions, Warning.
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    Patients are at low risk during the first 5 years of treatment. Other major risk factors include renal disease, concominant drug use e.g. tamoxifen, and macular disease which is thought to potentially affect screening and susceptibility to Plaquenil and chloroquine. The pharmacological activity of chloroquine and hydroxychloroquine was tested using SARS-CoV-2 infected Vero cells. Physiologically-based pharmacokinetic models PBPK were implemented for both drugs separately by integrating their in vitro data. Using the PBPK models, hydroxychloroquine concentrations in lung fluid were simulated under 5. Applies to hydroxychloroquine oral tablet. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine

     
  5. Sokols XenForo Moderator

    Hydroxychloroquine is widely used in the treatment of post-Lyme arthritis. Early Plaquenil Toxicity Detected without Bull’s Eye Maculopathy Despite Plaquenil dosing recommendations, retinal toxicity. The Risk of Retinal Toxicity with Plaquenil
     
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    Immune & Autoimmune - Lupus Plaquenil - Can It Work Quickly? Hi Guys, I haven't been here for a while - just checked in and found this question on Plaquenil - for me it took approx nine weeks to begin to work - I'm only taking 200mg per day so far - it seemed to stop working a few weeks later - most days are pretty good I s'pose but I drop nearly every afternoon.

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