Chloroquine is now uncommonly used in favor of its derivative hydroxychloroquine. In the United States, hydroxychloroquine is most often used for its anti-inflammatory effects in rheumatology and dermatology. Plaquenil 250 Chloroquine molecular formula Any daily dose of greater than 400 mg and being prescribed a maintenance dose of more than 6.5 mg/kg/day may increase the likelihood 1. Duration of treatment. Taking Plaquenil for more than 5 years and if the total amount taken by the patient reaches more than 1000 g may put the patient at risk for the toxicity 1. Patient characteristics Initial dose 400 mg 310 mg base orally 1 to 2 times a day; this dose may be continued for several weeks or months, depending on patient response. Maintenance dose 200 to 400 mg 155 to 310 mg base orally daily. Comments -Each dose should be taken with a meal or a glass of milk. A cumulative dose of 1000g HCQ is reached in 7 years with a typical daily dose of 400 mg. In the same study, toxicity was not related to age, weight or daily dose but was related to duration of use and increased rapidly after 5 to 7 years; thus, it is important to be aware of the risk factors and use more effective protocols of screening on all. While early toxicity may be asymtomatic, patients with more advanced stage of toxicity may complain of color vision changes or paracentral scotomas. Its toxic effects on the retina are seen in the macula. Plaquenil daily dose to minimize retinopathy Drug spotlight on hydroxychloroquine Lupus Foundation of., Hydroxychloroquine Dosage Guide with Precautions - Plaquenil cause depressionSide effects of chloroquine overdoseHow common is diarrhea with plaquenilWill plaquenil show up on a drug screenChloroquine tfeb Feb 19, 2020 The recommended adult dosage is 200 to 400 mg 155 to 310 mg base daily, administered as a single daily dose or in two divided doses. Doses above 400 mg a day are not recommended. The incidence of retinopathy has been reported to be higher when this maintenance dose is exceeded. Plaquenil Hydroxychloroquine Uses, Dosage, Side Effects.. Retinal toxicity associated with chronic exposure to.. Plaquenil Risk Calculators. Mar 10, 2017 Rapid onset toxic retinopathy has been reported in two out of seven patients being treated with erlotinib and high dose HCQ 1000 mg daily for non-small cell lung cancer. 50 The affected patients. The usual dosage works for most people who take Plaquenil, but it is possible to increase or decrease the dose based on individual needs. It's important to watch for possible side effects and toxicity. For people who weigh less than 80 kg, a lower daily dose is prescribed, up to a maximum of 5 mg/kg of body weight. Oct 23, 2006 She said she was treated with 200mg to 400mg of Plaquenil hydroxychloroquine sulfate, Sanofi-Synthelabo per day for her lupus 4.4mg/kg to 8.8 mg/kg per day for two years with a cumulative dose of 276g. The patient said she was also prescribed prednisone for her lupus; the dose had been tapered from 5mg/day to 1mg/day.