Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Chloroquine treatment of amoebic liver abscess Plaquenil and quinine Hydroxychloroquine is in a class of drugs called antimalarials. It is used to prevent and treat acute attacks of malaria. It is also used to treat discoid or systemic lupus erythematosus and rheumatoid arthritis in patients whose symptoms have not improved with other treatments. Side Effects Nausea, stomach cramps, loss of appetite, diarrhea, dizziness, or headache may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly. Remember. Hydroxychloroquine is generally the first line of treatment for someone who has been diagnosed with lupus. It is used for skin and joint involvement, muscle inflammation, fever, fatigue, pleurisy, to reduce the development of renal kidney disease and chronic damage, and for its steroid-sparing properties. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Hydroxychloroquine tiredness Hydroxychloroquine - Wikipedia, Plaquenil Oral Uses, Side Effects, Interactions, Pictures. Plaquenil and prednisone will i lose weight or gain weightPlaquenil and cnsLysosomal inhibitor chloroquineCombination treatment prednisone and plaquenil for ankylosing spondylitisAntimalarial resistance chloroquine Hydroxychloroquine Plaquenil, chloroquine Aralen, and quinacrine Atabrine are medications that were originally used to prevent or treat malaria. However, during World War II it was also found that these medications were effective in treating the symptoms of lupus. Treating Lupus with Anti-Malarial Drugs Johns Hopkins Lupus.. Hydroxychloroquine Prescriptions - LUPUS UK. Is extreme fatigue a side effect of Plaquenil?. Side effects include irritability, headache, weakness, hair lightening or loss, stomach upset, nausea, dizziness, muscle pain, rash and itching. Rarely, hydroxychloroquine can affect the bone marrow leading to reduced white blood cells leukopenia or platelets thrombocytopenia. May 23, 2016 Plaquenil hydroxychloroquine is a medication that has been used for many years to help musculoskeletal symptoms and fatigue in patients with autoimmune conditions such as rheumatoid arthritis, lupus and Sjögren’s. But I'm really struggling with fatigue now - worse than its ever been. Don't know whether its the RA itself or my body reacting to Plaquenil but I can't seem to do anything without being really really tired. I wake up tired, I have a wash and it wipes me out, I have a nap and I'm tired and in the evening, I have zilch energy for anything.