The exact physiopathology of this disease is not known and there is no specific treatment for it. There is merely news from a few previous descriptions in the literature about the use of hydroxychloroquine for surfactant protein C deficiency with satisfactory results. Malaria chloroquine Plaquenil visual side effects What do hydroxychloroquine do Plaquenil and breast cancer Hydroxychloroquine and Surfactant Protein C Deficiency Article in New England Journal of Medicine 3522207-8 February 2005 with 222 Reads How we measure 'reads' SFTPC surfactant protein C mutations resulting in SP-C deficiency causing ongoing respiratory failure in the neonatal period represent a rare entity. We report a full-term female infant who. The diagnosis of a surfactant protein C mutation c.545 GC.pGly182Arg was confirmed by genetic testing once available. Patient 1 had a family history of a maternal uncle dying of pneumonia at 6 months of age and a maternal grandfather dying of lung disease at 49 years of age, but neither one had genetic studies performed. These data seem to cast some doubt on the efficacy of hydroxychloroquine, and they suggest that the clinical improvement was simply the natural evolution of the disease. Two years after the treatment was withdrawn, the twins were evaluated once again: they presented no new infections, growth and general state were normal and chest CT showed a notable additional reduction in the interstitial pneumopathy. Surfactant protein c deficiency hydroxychloroquine Hydroxychloroquine and Surfactant Protein C Deficiency Request PDF, Successful treatment of neonatal respiratory failure. Hydroxychloroquine sudden neck stiff neck painBest malaria medication for prevention of chloroquine-resistant malariaPlaquenil drug name We present the case of two twin brothers with surfactant protein C deficiency who were treated with hydroxychloroquine for three years, with apparent success. The exact physiopathology of this disease is not known and there is no specific treatment for it. Is Treatment With Hydroxychloroquine Effective in.. Chronic Ventilation in Infants with Surfactant Protein C.. Surfactant protein C - Wikipedia. Protein C Deficiency. We present the case of two twin brothers with surfactant protein C deficiency who were treated with hydroxychloroquine for three years, with apparent success.nih.gov C deficiency. Surfactant protein C deficiency is characterised by deficiency of the protein and its intracellular accumulation, with subsequent local inflammation and interstitial lung disease. There is no specific treatment, but hydroxychloroquine has been reported to be effective. Hydroxychloroquine and Surfactant Protein C Deficiency to the editor We wish to report initial success in treating a boy with surfactant protein C deficiency.