Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Chloroquine mechanism of action lysosome Glutathione plaquenil hyperpigmentation Mar 01, 2004 Massive hydroxychloroquine overdose A 17‐year‐old girl presented to the Emergency Department 45 min after the ingestion of 22 g of hydroxychloroquine in a suicide attempt. We believe this is highest dose yet reported in the medical literature. Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning 20 g in each case, both of which received advanced cardiac life support and a treatment regimen consisting of sodium A 17 year old girl, believed to have ingested an overdose of her mother's medication, was found comatose and died after several hours of resuscitative efforts; she had hydroxychloroquine concentrations of 7.5 mg/L in antemortem blood, 20 mg/L in postmortem heart blood and 220 mg/kg in liver Treacy, 1999. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Massive hydroxychloroquine overdose Hydroxychloroquine overdose, Reactions Weekly 10.1007., Survival after Massive Hydroxychloroquine Overdose Plaquenil and heart rateWhy do some supplements call generic hydroxychloroquine brand nameHow long for plaquenil to start working Hydroxychloroquine sulfate is a chloroquine derivative in which 1 of the N-ethyl groups is β-hydroxylated. Its therapeutic action against falciparum malaria is similar to that of chloroquine. Its therapeutic action against falciparum malaria is similar to that of chloroquine. Effectiveness of Chloroquine and Hydroxychloroquine in.. Hydroxychloroquine - Biomedical Publications. Massive hydroxychloroquine overdose - Yanturali - 2004.. Common hydroxychloroquine side effects may include headache, dizziness, ringing in your ears; nausea, vomiting, stomach pain; loss of appetite, weight loss; mood changes, feeling nervous or irritable; skin rash or itching; or. hair loss. Commonly used on holidays in malaria prone destinations, chloroquine and hydroxychloroquine will not be over familiar to the emergency physician. However, it is one of the leading causes of drug overdose in malaria prone countries and also the occasional toddler has managed to consume the grandparents lupus or rheumatoid arthritis medication leading to lethal consequences. Hydroxychloroquine overdose is infrequently reported and the majority of recommendations come from the greater experience with chloroquine poisoning. We report two cases of massive hydroxychloroquine poisoning 20 g in each case, both of which received advanced cardiac life support.