Plaquenil macular changes

Discussion in 'Aralen' started by dimedrolll, 25-Feb-2020.

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    Plaquenil macular changes


    In Sjögren’s, Plaquenil is used to treat many symptoms of Sjögren’s including fatigue, joint symptoms of arthritis and arthralgias (joint pain), dry mouth and dry eyes. Similar to its use in systemic lupus erythematosus, many clinicians feel that it is useful in reducing general Sjögren’s “disease activity.” One of the reasons that physicians feel comfortable in prescribing Plaquenil is its low risk to benefit ratio.

    Hydroxychloroquine adv Chloroquine endosomal escape Hydroxychloroquine sun skin

    Hydroxychloroquine typically is very well tolerated. Serious side effects are rare. The most common side effects are nausea and diarrhea, which often improve with time. Less common side effects include rash, changes in skin pigment such as darkening or dark spots, hair changes, and muscle weakness. Plaquenil induced retinal toxicity is reversible if detected early and plaquenil dosage altered or the medication discontinued. Even suspicious early plaquenil toxicity warrants communication with the patient’s treating physician, and meaningful coordination of care would include a report even if the findings are normal. Symptoms of Plaquenil toxicity are similar to other macular problems and may include Decreased fine vision or difficulty reading. Changes in Color vision. Missing Spots or shadows near the center of the vision.

    As with any medication, allergic reactions including skin rashes and non-allergic reactions can occur. This means that the side effects of Plaquenil are mild and infrequent compared with its potential benefits.

    Plaquenil macular changes

    Hydroxychloroquine-Induced Retinal Toxicity - American., Plaquenil-Induced Toxic Maculopathy - Decision-Maker PLUS

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  4. Nov 01, 2015 H ydroxychloroquine HCQ; Plaquenil, Sanofi, Bridgewater, NJ is an antimalarial agent that is also commonly used as a treatment for a variety of rheumatologic and dermatologic conditions, such as rheumatoid arthritis and systemic lupus erythematosus. The most common side effect associated with its use is retinal toxicity, which may be irreversible.

    • Retinal Physician - Hydroxychloroquine Maculopathy An Update..
    • Plaquenil Toxicity Screening - Retina Group of New York.
    • Retina Today - Imaging in Hydroxychloroquine Toxicity April..

    Hydroxychloroquine Retinopathy with SD-OCT Changes and Minimal Fundus Changes The images shown here refer to the same case as "Hydroxychloroquine Retinopathy with Minimal Fundus Changes". This 68 year old woman with systemic lupus erythematosus had been on hydroxychloroquine at a dosage of 400 mg/d 6.52 mg/kg/d for eight years. Aug 29, 2014 Several risk factors may increase the likelihood of retinal toxicity from Plaquenil such as, age of greater than 60 years, daily dose more than 6.5 mg/kg; use of the drug more than 5 years, obesity, preexisting retinal disease and, renal or liver failure. Detecting local changes in the macula Of note, mfERG can vary 10-30% from session to session and to find definitive changes, a series of mfERG recordings needs to be done9,10 Significant cataracts can affect the outcome of the mfERG12 • In studies, 20-60% of patients receiving Plaquenil were found to have

     
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    Selected from data included with permission and copyrighted by First Databank, Inc. Hydroxychloroquine Plaquenil Side Effects & Dosage for. Terrible Itching on Plaquenil---PLEASE HELP. Medication Cautions in Macular Degeneration - AMDF
     
  6. Aralen, Chloroquine phosphate chloroquine dosing. Irreversible retinal damage observed in some patients; significant risk factors for retinal damage include daily doses of chloroquine phosphate 2.3 mg/kg of actual body weight, durations of use greater than five years, subnormal glomerular filtration, use of some concomitant drug products such as tamoxifen citrate, and concurrent macular disease.

    Chloroquine MedlinePlus Drug Information