Hydroxychloroquine retinopathy dose

Discussion in 'Aralen' started by Dregi, 11-Mar-2020.

  1. andrm Guest

    Hydroxychloroquine retinopathy dose


    She suffered from Sjogren syndrome and inflammatory arthritis and was currently treated with prednisone and methotrexate. She was previously treated with hydroxychloroquine (Plaquenil) 200mg bid (6.5mg/kg) for 10 years, which was stopped one year prior to presentation.

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    Marmor MF, Kellner U, Lai TYY, Melles RB, Mieler WF, for the American Academy of Ophthalmology. Recommendations on screening for chloroquine and hydroxychloroquine retinopathy 2016 revision. Ophthalmology 2016;186-1394. Melles RB, Marmor MF. The risk of toxic retinopathy in patients on long-term hydroxychloroquine therapy. Characteristics of individual patients screened for possible hydroxychloroquine HCQ retinopathy Duration, Daily HCQ Total HCQ Daily HCQ Patient Age Raceisex* Diagnosis? years dosage, rng dose, grn dosage, mgikg 1 48 WIF SLE 7.3 400 1,066 6.98 2 77 WIF RA, TIA 3.5 400 511 6.82 3 69 WIF RA 4.8 200 343 3.44 Hydroxychloroquine breaks down into two pharmacologically active metabolites — desethyl-hydroxychloroquine and desethyl-chloroquine. After a single dose, hydroxychloroquine is excreted mainly in the faeces, and only 20% is excreted unchanged in the urine. Dose adjustment is therefore only required in patients with severe renal impairment.

    Review of systems: Blurred vision, halos, dry eye, dry mouth, gastroesophageal reflux, joint pain Pupils: Reactive to light in each eye from 5 mm in the dark to 2 mm in the light. Extraocular movements: Full, both eyes (OU) Confrontation visual fields: Full OU Intra-ocular pressure The optic nerves appeared healthy with a 0.3 cup-to-disc ratio. Past Ocular History: None Medical History: Sjogren syndrome and inflammatory arthritis, supraventricular tachycardia, anxiety, depression, peptic ulcer disease Medications: prednisone, methotrexate, amitriptyline, ranitidine, estradiol, tizanidine, diltiazem, Restasis Allergies: codeine, droperidol Family History: heart disease, arthritis, cancer Social History: occasional alcohol but no tobacco or intravenous drug use.

    Hydroxychloroquine retinopathy dose

    Retinopathy after long term, standard doses of., Incidence of hydroxychloroquine retinopathy in 1,207.

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  6. Nov 25, 2019 Detailed Hydroxychloroquine dosage information for adults and children. Includes dosages for Rheumatoid Arthritis, Systemic Lupus Erythematosus, Malaria Prophylaxis and more; plus renal, liver and dialysis adjustments.

    • Hydroxychloroquine Dosage Guide with Precautions -.
    • Hydroxychloroquine DermNet NZ.
    • Hydroxychloroquine and Chloroquine Retinopathy..

    Oct 07, 2019 Study researchers concluded that hydroxychloroquine blood level testing may effectively predict the risk for retinopathy, and give clinicians an insight as to whether to decrease hydroxychloroquine dose or increase monitoring in patients with high hydroxychloroquine blood levels. Reference. Petri M, Elkhalifa M, Li J, Magder LS, Goldman DW. Medication Dosage. Several factors have been associated with the risk of developing hydroxychloroquine retinopathy. One of the most important appears to be dosage—with debate over whether daily intake vs. cumulative dosage is most significant. Jan 05, 2020 Hydroxychloroquine retinopathy is most influenced by daily dose and duration of use. Risk for toxicity is less with 5.0 mg/kg real weight/day for hydroxychloroquine and 2.3 mg/kg real weight/day for chloroquine. Patients are at low risk during the first 5 years of treatment.

     
  7. dreamhouse Moderator

    Plaquenil is the brand name for the prescription drug hydroxychloroquine. Having issues with Plaquenil - Claritin and Plaquenil drug interactions - eHealthMe Compare Plaquenil vs Chloroquine -
     
  8. mfender Moderator

    Plaquenil Brand vs Generic I started on the generic for the first few weeks. My eyes ached and my vision was blurry. So I switched to the brand name and immediately my eyes stopped aching and the eyesight cleared up. HOWEVER, for the other symptoms, the generic seemed to work better then the brand name. Unless I"m just getting sicker. which very well could be.

    Hydroxychloroquine Plaquenil Side Effects & Dosage for Malaria
     
  9. Tigrozavr Well-Known Member

    Plaquenil Dosage Guide - Rheumatoid Arthritis. The action of hydroxychloroquine is cumulative and may require weeks to months to achieve the maximum therapeutic effect see CLINICAL PHARMACOLOGY. Initial adult dosage 400 mg to 600 mg 310 to 465 mg base daily, administered as a single daily dose or in two divided doses. In a small percentage of patients, side effects may require temporary reduction of the initial.

    Hydroxychloroquine Side Effects Common, Severe, Long Term.